HaloPROTAC 2 Chemical Properties

Boiling point:

940.5±65.0 °C(Predicted)

Density 

1.200±0.06 g/cm3(Predicted)

storage temp. 

-80°C, protect from light, stored under nitrogen

solubility 

DMSO : ≥ 50 mg/mL (63.82 mM)

pka

13.54±0.46(Predicted)

form 

Viscous Liquid

HaloPROTAC 2 Usage And Synthesis

Description

HaloPROTAC2 is a novel HaloPROTAC degrader, inducing degradation of HaloTag fusion proteins.

Uses

VH032-PEG5-C6-Cl (HaloPROTAC 2) is a conjugate of ligands for E3 and 21-atom-length linker. The connector of linker is Halogen group. VH032-PEG5-C6-Cl incorporates the VH032 based VHL ligand and 5-unit PEG linker. VH032-PEG5-C6-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

IC 50

VHL

References

[1] Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7. DOI:10.1021/acschembio.5b00442

HaloPROTAC 2(1799506-06-1)Related Product Information

• E3 ligase Ligand-Linker Conjugates 29
• VH 032 phenol-linker 1
• (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-6,9,12-trioxa-3-azapentadec-14-yn-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
• VH032 thiol
• VH 101, phenol