E3 ligase Ligand-Linker Conjugates 29
E3 ligase Ligand-Linker Conjugates 29 Basic information
- Product Name:
- E3 ligase Ligand-Linker Conjugates 29
- Synonyms:
-
- E3 ligase Ligand-Linker Conjugates 29
- VH032-thiol-C6-NH2
- VHL Ligand-Linker Conjugates 14
- (2S,4R)-1-[(2R)-3-[(6-aminohexyl)sulfanyl]-2-acetamido-3-methylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
- L-Prolinamide, N-acetyl-3-[(6-aminohexyl)thio]-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
- CAS:
- 2098836-63-4
- MF:
- C29H43N5O4S2
- MW:
- 589.82
- Mol File:
- 2098836-63-4.mol
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E3 ligase Ligand-Linker Conjugates 29 Chemical Properties
- Boiling point:
- 868.6±65.0 °C(Predicted)
- Density
- 1.232±0.06 g/cm3(Predicted)
- pka
- 14.05±0.40(Predicted)
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E3 ligase Ligand-Linker Conjugates 29 Usage And Synthesis
Uses
VH032-thiol-C6-NH2 (VHL Ligand-Linker Conjugates 14) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology.
IC 50
VHL
References
[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329
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