VH 032 phenol-linker 1
VH 032 phenol-linker 1 Basic information
- Product Name:
- VH 032 phenol-linker 1
- Synonyms:
-
- VH 032 phenol-linker 1
- VH 032 phenol-alkylC4-amine
- (S,R,S)-AHPC-phenol-C4-NH2 (dihydrochloride)
- VH 032 phenol-alkylC4-amine dihydrochloride
- (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-N-(2-(4-aminobutoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride
- (2S,4R)-1-[(S)-2-Acetamido-3,3-dimethylbutanoyl]-N-[2-(4-aminobutoxy)-4-(4-methyl-5-thiazolyl)benzyl]-4-hydroxypyrrolidine-2-carboxamide Dihydrochloride
- CAS:
- 2376990-26-8
- MF:
- C28H42ClN5O5S
- MW:
- 596.18
- Mol File:
- 2376990-26-8.mol
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VH 032 phenol-linker 1 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to off-white
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VH 032 phenol-linker 1 Usage And Synthesis
Uses
(S,R,S)-AHPC-phenol-C4-NH2 (VH032-phenol-C4-NH2) dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC?based VHL ligand and a linker used in?PROTAC?technology[1].
storage
Store at -20°C
References
[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery.?Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] [3].Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
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