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VH 101, phenol

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VH 101, phenol Basic information

Product Name:
VH 101, phenol
Synonyms:
  • E3 ligase Ligand 19
  • VH032-cyclopropane-F
  • VH 101, phenol
  • (2S,4R)-1-((S)-2-(1-fluorocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
  • (2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
  • Phenolic VH101
  • Inhibitor,E3 ligase-recruiting Moiety,inhibit,VHL ligand3,Ligands for E3 Ligase,VH032 cyclopropane F,VH032cyclopropaneF,VHL ligand-3,VH-032-cyclopropane-F
CAS:
2306193-99-5
MF:
C26H33FN4O5S
MW:
532.63
Mol File:
2306193-99-5.mol
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VH 101, phenol Chemical Properties

Boiling point:
841.7±65.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
solubility 
Soluble in DMSO
pka
9.12±0.35(Predicted)
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VH 101, phenol Usage And Synthesis

Uses

VH032-cyclopropane-F (VH 101, phenol) is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal hydroxyl group. Allows rapid conjugation with many linkers containing active leaving groups. A basic building block for development of a protein degrader library.

storage

Store at +4°C

VH 101, phenolSupplier

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