Ethyl 3-(4-fluorophenyl)-3-oxopropanoate Chemical Properties

Melting point:

117-120℃

Boiling point:

117-120 °C(lit.)

Density 

1.174 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.5040(lit.)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

clear liquid

pka

9.82±0.25(Predicted)

Specific Gravity

1.19

color 

Colorless to Almost colorless

InChIKey

SJUXLKYJKQBZLM-UHFFFAOYSA-N

CAS DataBase Reference

1999-00-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Safety Statements 

24/25

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29183000

MSDS

• Language:English Provider:SigmaAldrich

Ethyl 3-(4-fluorophenyl)-3-oxopropanoate Usage And Synthesis

Chemical Properties

Colorless liquid

Uses

Reactant used as a precursor in:

• Condensation reactions with diamines via C-C bond cleavage for synthesis of benzimidazoles and perimidines for possible use as antimalarial treatments
• Base-promoted domino Michael addition / cyclization / elimination reactions for synthesis of hydroxybenzophenones
• Oxidative cross-coupling with indoles via dioxygen activation
• Cyclization of keto esters for synthesis of pyrones
• Lewis base catalyzed hydrosilylation for synthesis of α-acetoxy β-amino acid derivatives
• Conia-ene reactions for synthesis of methylenecyclopentane derivatives

General Description

Ethyl (4-fluorobenzoyl)acetate on condensation with benzofurazan oxide yields 2-(carboethoxy)-3-(4′-fluoro)phenylquinoxaline1,4-dioxide.

Ethyl 3-(4-fluorophenyl)-3-oxopropanoate(1999-00-4)Related Product Information

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