DL-PENICILLAMINE Chemical Properties

Melting point:

204-208 °C(lit.)

Boiling point:

251.8±35.0℃ (760 Torr)

Density 

1.204±0.06 g/cm3 (20 ºC 760 Torr)

refractive index 

1.5216 (estimate)

Flash point:

106.1±25.9℃

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

Methanol (Slightly), Water (Soluble)

pka

pK: 1.8 (carboxyl); 7.9 (a-amino); 10.5 (b-thiol)

form 

solid

Water Solubility 

Soluble in ethanol, hot water and sodium hydroxide.

Merck 

14,7088

BRN 

2039817

CAS DataBase Reference

52-66-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38-40-20/21/22

Safety Statements 

26-36-22

WGK Germany 

3

RTECS 

YV9445000

HS Code 

29309099

Toxicity

LD50 orally in rats: 365 mg/kg (Jaffe)

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

DL-PENICILLAMINE Usage And Synthesis

Application in Rheumatic Arthritis

Penicillamine onset may be seen in 1 to 3 months, and most responses occur within 6 months. Early adverse effects include skin rash, metallic taste, hypogeusia, stomatitis, anorexia, nausea, vomiting, and dyspepsia. Glomerulonephritis may occur, which manifests as proteinuria and hematuria. Penicillamine is usually reserved for patients who are resistant to other therapies because of the rare but potentially serious induction of autoimmune diseases (e.g., Goodpasture’s syndrome, myasthenia gravis).

Chemical Properties

white to almost white crystalline powder

Uses

antirheumatic, chelating agent (copper), Wilson's desease treatment

Uses

DL-Penicillamine is a penicillin metabolite used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.

Definition

ChEBI: An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.

Safety Profile

Poison by ingestion and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx.

DL-PENICILLAMINE(52-66-4)Related Product Information

• Ampicillin
• DL-4-Chlorophenylalanine
• DL-4-Cyanophenylalanine
• 2-AMINO-3-(3-METHOXY-PHENYL)-PROPIONIC ACID
• 2-Bromo-DL-Phenylalanine
• DL-3-(4-Fluorophenyl)alanine
• Mecillinam
• 6-Aminopenicillanic acid
• D-Penicillamine
• Dicloxacillin sodium
• DL-PENICILLAMINE
• Penicillin G potassium salt
• N-Acetyl-DL-penicillamine hemihydarate,N-ACETYL-DL-PENICILLAMINE 98%,N-ACETYL-DL-PENICILLAMINE,ACETYL-DL-PENICILLAMINE, N-
• Mezlocillin
• D-PENICILLAMINE DISULFIDE
• OXACILLIN SODIUM
• Cloxacillin-13C4 SodiuM Salt
• S-Benzyl-DL-Penicillamine