4,4'-OXYBIS(PHENYL ISOCYANATE) Chemical Properties

Melting point:

64-68 °C(lit.)

Boiling point:

196 °C5 mm Hg(lit.)

Density 

1.2700 (rough estimate)

refractive index 

1.5910 (estimate)

solubility 

Acetonitrile (Soluble)

form 

Solid

color 

White to Off-White

Stability:

Moisture Sensitive

CAS DataBase Reference

4128-73-8

EPA Substance Registry System

4,4'-Diisocyanatodiphenyl ether (4128-73-8)

Safety Information

Hazard Codes 

Xn,T+

Risk Statements 

20/21/22-36/37/38-42/43-26-25-21

Safety Statements 

23-26-36/37/39-45-36/37-28-22

RIDADR 

UN 2206 6.1/PG 3

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

4,4'-OXYBIS(PHENYL ISOCYANATE) Usage And Synthesis

Chemical Properties

WHITE CRYSTALLINE SOLID

Uses

4,4'-Bis(isocyanatophenyl)oxide is a reagent used in the synthesis of lipid-conjugated Smac analogs with antitumor activity against human breast cancer cell lines.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.

Reactivity Profile

Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Polyurethanes are formed by the condensation reaction of diisocyanates with, for example, ethyl glycol.

4,4'-OXYBIS(PHENYL ISOCYANATE)(4128-73-8)Related Product Information

• 1,4-Phenylene diisocyanate
• 4-PHENOXYPHENYL ISOCYANATE
• 4,4'-Oxydianiline
• 4,4'-OXYBIS(PHENYL ISOCYANATE)
• 4-Methoxyphenyl isocyanate