HYPOCRELLIN A
HYPOCRELLIN A Basic information
- Product Name:
- HYPOCRELLIN A
- Synonyms:
-
- HYPOCRELLIN
- HYPOCRELLIN A
- 1H-Cyclohepta[ghi]perylene-5,12-dione,1-acetyl-2,3-dihydro-2,6,11-trihydroxy-4,8,9,13-tetramethoxy-2-methyl-,stereoisomer
- (1S,2R)-1-acetyl-2,5,12-trihydroxy-4,8,9,13-tetramethoxy-2-methyl-2,3-dihydro-1H-cyclohepta[ghi]perylene-6,11-dione
- (11R,12S)-11-acetyl-3,9,12-trihydroxy-1,5,6,10-tetramethoxy-12-methyl-12,13-dihydro-2H-cyclohepta[ghi]perylene-2,8(11H)-dione
- (1S,2R)-1-acetyl-2,5,12-trihydroxy-4,8,9,13-tetramethoxy-2-m...
- 11-epoxide
- Dexamethasone 9
- CAS:
- 77029-83-5
- MF:
- C30H26O10
- MW:
- 546.52
- Mol File:
- 77029-83-5.mol
HYPOCRELLIN A Chemical Properties
- Melting point:
- 209-210 °C
- Boiling point:
- 922.8±65.0 °C(Predicted)
- Density
- 1.55±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF: 2mg/mL; DMSO: 3mg/mL; Ethanol: 0.3mg/mL
- form
- A solid
- pka
- 7.03±0.60(Predicted)
- color
- Brown to red
- InChIKey
- URTOHKHBNYPGQJ-UHYDGBJBNA-N
- SMILES
- C12C3[C@@H](C(=O)C)[C@](O)(C)CC4=C(C(=O)C5=C(C=C(OC)C(C6C(OC)=CC(=O)C(=C(O)C=3OC)C1=6)=C5C=24)O)OC |&1:2,6,r|
HYPOCRELLIN A Usage And Synthesis
Chemical Properties
Red crystal, odorless, tasteless, purity 98%, melting point 209-210 ℃, soluble in chloroform, acetone, ethyl acetate, soluble in methanol, ethanol, slightly soluble in petroleum ether, insoluble in water, not easy to hydrolysis, but in the alkaline environment can be self-sensitive photo-oxidation of photolysis; now the folk used as a drug to treat gastric pain and arthritis and is the treatment of dermatological disorders, anti-tumor, anti-AIDS, the potentially effective It is also a potentially effective photosensitive drug for the treatment of skin diseases, anti-tumor and anti-AIDS.
Uses
Hypocrellin A is an antimicrobial and antileishmanial activity. Ga(3+)-Hypocrellin interacts with myoglobin in vitro.
in vivo
Hypocrellin A (2.5 and 5 mg/kg; i.p.; once every two days for fourteen days) inhibits tumor growth in a non-small cell lung cancer xenograft model mouse model[8].
| Animal Model: | H460 cells were inoculated subcutaneously on the backs of BALB/c nude mice[8] |
| Dosage: | 2.5 and 5 mg/kg |
| Administration: | i.p.; Inject once every two days for fourteen days |
| Result: | Induced the expression of the pro-apoptotic protein BAX and inhibited the expression of the anti-apoptotic protein BCL-2 in NSCLC tumors. |
IC 50
Leishmania
HYPOCRELLIN ASupplier
- Tel
- 0572-8889530 18167260939
- zsubio@163.com
- Tel
- 4009903999 13355009207
- 3007715519@qq.com
- Tel
- 0871-65217109 13211707573;
- y.liu@mail.biobiopha.com
- Tel
- 021-61312847 13636370518
- shyysw007@163.com
- Tel
- +86-028-82633397 18982077548
- cwb1@biopurify.cn
HYPOCRELLIN A(77029-83-5)Related Product Information
- HYPOCRELLIN B, HYPOCRELLA BAMBUSAE,HYPOCRELLIN B
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