Hydroxyzine dihydrochloride CAS#: 2192-20-3

Hydroxyzine dihydrochloride Basic information

Product Name:

Hydroxyzine dihydrochloride

Synonyms:

ateraxdihydrochloride
dichlorhydratede1-p.chlorbenzhydryl-4-(2-(2-hydroxyethoxy)ethyl)piperazine
neurolax
orgatrax
tran-qdihydrochloride
Disron
Hydroxyzine Hydrochloride (500 mg)
Hydroxyzine Di Hcl

CAS:

2192-20-3

MF:

C21H29Cl3N2O2

MW:

447.83

EINECS:

218-586-3

Product Categories:

Intermediates & Fine Chemicals
Pharmaceuticals
InhibitorsMulti-Drug Resistance and Drug Metabolism
Aromatics
Piperazines
API
Cell Signaling Enzymes
Drug and Xenobiotic Metabolism
Substrates, Inducers, Inhibitors
Xenobiotics and Drug Metabolism
Heterocycles

Mol File:

2192-20-3.mol

More

Less

Hydroxyzine dihydrochloride Chemical Properties

Melting point:: 190-192°C
Flash point:: 9℃
storage temp.: 2-8°C
solubility: H₂O: soluble
form: powder
color: White to Off-White
CAS DataBase Reference: 2192-20-3(CAS DataBase Reference)
EPA Substance Registry System: Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride (2192-20-3)

More

Less

Safety Information

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3
RTECS: KK2280000
HS Code: 29335990
Toxicity: LD50 in rats (mg/kg): 126 i.p.; 950 orally (Goldenthal)

MSDS

Language:English Provider:SigmaAldrich

More

Less

Hydroxyzine dihydrochloride Usage And Synthesis

Chemical Properties

White Solid

Originator

Atarax,UCB,France,1956

Uses

Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.

Uses

Antihistaminic;H1 antogonist

Uses

Anti histamines

Uses

H1 receptor antagonist. Anxiolytic. Antihistaminic.

Manufacturing Process

A mixture of 0.1 mol of N-mono-1-p-chlorobenzohydrylpiperazine and 0.1 mol of 1-chloro-2-(2-hydroxy-ethoxy)-ethane is heated for 3 hours to 150°C. The mass is then taken up in 100 ml of benzene and 100 ml of a 10% aqueous solution of NaOH; decanting takes place, and the benzene solution is washed with water and the solvent is evaporated. Vacuum distilling of the residue yields 1-p-chlorobenzohydryl-4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazine, BP 220°C/0.5 mm Hg.
The corresponding dihydrochloride is prepared by dissolving this base in about twice its weight of alcohol, by treating it with excess of gaseous HCl and by precipitating it with ether. The solvent is decanted and the residue, dissolved in a minimum of alcohol, crystallizes on the addition of ether, MP 193°C.

brand name

Amplimexon (Amplimed).

Therapeutic Function

Tranquilizer

General Description

Hydroxyzine dihydrochloride is an antihistaminic drug and a member of the diphenylmethanes family. It exerts its action by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biochem/physiol Actions

Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.

Hydroxyzine dihydrochloride Preparation Products And Raw materials

Raw materials

Chlorodiphenylmethane 1-(2-(2-hydroxy ethoxy)ethyl)perazine

Hydroxyzine dihydrochlorideSupplier

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Email: jkinfo@jkchemical.com

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Email: 2355560935@qq.com

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Email: sales@jingyan-chemical.com

LGM Pharma

Tel: 1-(800)-881-8210
Email: inquiries@lgmpharma.com

More

Less