Xentuzumab
Xentuzumab Basic information
- Product Name:
- Xentuzumab
- Synonyms:
-
- Xentuzumab
- Research Grade Xentuzumab
- Xentuzumab (anti-IGF1)
- BI 836845
- CAS:
- 1417158-65-6
- MW:
- 0
- Mol File:
- Mol File
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Xentuzumab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
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Xentuzumab Usage And Synthesis
Uses
Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant a human monoclonal antibody that targets IGF ligands IGF1 and IGF2. Xentuzumab inhibits both of IGF1 and IGF2 growth-promoting signalling and suppresses AKT activation[1].
in vivo
Xentuzumab (200 mg/kg i.p., once weekly for 10 weeks) in inhibits tumor growth in LuCaP 96CR patient-derived xenograft model in mice[1].
| Animal Model: | Fox Chase CB17 severe combined immunodeficiency (SCID; CB17/lcr-Prkdc scid/lcrlcoCrl) male mice with LuCaP 96CR cell (s.c.)[1] |
| Dosage: | 200 mg/kg |
| Administration: | Intraperitoneal injection; once weekly for 10 weeks; sacrificed 6 hours after the last dose |
| Result: | Resulted in significant reductions in tumor volume. |
References
[1] Weyer-Czernilofsky U, et al. Antitumor Activity of the IGF-1/IGF-2-Neutralizing Antibody Xentuzumab (BI 836845) in Combination with Enzalutamide in Prostate Cancer Models. Mol Cancer Ther. 2020 Apr;19(4):1059-1069. DOI:10.1158/1535-7163.MCT-19-0378
XentuzumabSupplier
Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
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TargetMol Chemicals Inc.
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Guangzhou Hongyuan Chemical Co.,Ltd
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- 15817493340
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Wuhan Chemstan Biotechnology Co., Ltd.
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- 027-65317797 15926423062
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