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procyclidine

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procyclidine Basic information

Product Name:
procyclidine
Synonyms:
  • Kemadrine
  • Vagosin
  • α-Cyclohexyl-α-phenyl-1-pyrrolidine-1-propanol
  • 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol
  • procyclidine
  • Tricyclamol
  • 1-Pyrrolidinepropanol, α-cyclohexyl-α-phenyl-
  • procyclidine USP/EP/BP
CAS:
77-37-2
MF:
C19H29NO
MW:
287.44
EINECS:
201-023-0
Mol File:
77-37-2.mol
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procyclidine Chemical Properties

Melting point:
85.5-86.5°
Boiling point:
429.73°C (rough estimate)
Density 
0.9954 (rough estimate)
refractive index 
1.5180 (estimate)
pka
14.21±0.29(Predicted)
Water Solubility 
1.055mg/L(22.5 ºC)
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Safety Information

Hazardous Substances Data
77-37-2(Hazardous Substances Data)
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procyclidine Usage And Synthesis

Uses

Antiparkinsonian; relaxant (skeletal muscle).

Definition

ChEBI: A tertiary alcohol that consists of propan-1-ol substituted by a cyclohexyl and a phenyl group at position 1 and a pyrrolidin-1-yl group at position 3.

brand name

Kemadrin (Monarch).

Synthesis

Procyclidine, 1-cyclohexyl-1-phenyl-3-pirrolidinopropan-1-ol (10.2.3), is synthesized in the exact same manner, except beginning with 2-(1-pyrrolidino) propiophenone [28–32].

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