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procyclidine

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procyclidine Basic information

Product Name:
procyclidine
Synonyms:
  • Kemadrine
  • Vagosin
  • α-Cyclohexyl-α-phenyl-1-pyrrolidine-1-propanol
  • 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol
  • procyclidine
  • Tricyclamol
  • 1-Pyrrolidinepropanol, α-cyclohexyl-α-phenyl-
  • procyclidine USP/EP/BP
CAS:
77-37-2
MF:
C19H29NO
MW:
287.44
EINECS:
201-023-0
Mol File:
77-37-2.mol
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procyclidine Chemical Properties

Melting point:
85.5-86.5°
Boiling point:
429.73°C (rough estimate)
Density 
0.9954 (rough estimate)
refractive index 
1.5180 (estimate)
pka
14.21±0.29(Predicted)
Water Solubility 
1.055mg/L(22.5 ºC)
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Safety Information

Hazardous Substances Data
77-37-2(Hazardous Substances Data)
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procyclidine Usage And Synthesis

Uses

Antiparkinsonian; relaxant (skeletal muscle).

Definition

ChEBI: A tertiary alcohol that consists of propan-1-ol substituted by a cyclohexyl and a phenyl group at position 1 and a pyrrolidin-1-yl group at position 3.

brand name

Kemadrin (Monarch).

Synthesis

Procyclidine, 1-cyclohexyl-1-phenyl-3-pirrolidinopropan-1-ol (10.2.3), is synthesized in the exact same manner, except beginning with 2-(1-pyrrolidino) propiophenone [28–32].

in vivo

Procyclidine (subcutaneous injection, 0.3-6.0 mg/kg) in combination with physostigmine (PhS) increases protection in a dose-dependent manner in rats and guinea pigs infected with soman and can prevent seizures altogether[1].

Animal Model:Male Sprague-Dawley rats, Dunkin-Hartley male guinea pigs[1]
Dosage:0.3-6.0 mg/kg
Administration:Subcutaneous injection; once
Result:Increased protection, resulting in 1.92, 2.24, 3.95 and 5.07 fold in rats, 3.00, 3.25, 4.50 and 4.70 fold in guinea pigs at the doses of 0.3, 1.0, 3.0 or 6.0 mg/kg, respectively.
Protected the neurological integrity of the brain and prevented Soman-induced severe brain damage in the hippocampus, cortex, amygdala and thalamus.

IC 50

NMDA Receptor

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