PROCYCLIDINE HYDROCHLORIDE Chemical Properties

Melting point:

159-164 °C

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22

Safety Statements 

36

WGK Germany 

3

RTECS 

UY1926000

HS Code 

2933997500

Toxicity

mouse,LD50,intravenous,14mg/kg (14mg/kg),BEHAVIORAL: TREMORLUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 383, 1955.

MSDS

• Language:English Provider:SigmaAldrich

PROCYCLIDINE HYDROCHLORIDE Usage And Synthesis

Uses

An anticholinergic drug used in the treatment parkinson’s disease. It is also used to treat patients suffering from drug-induced parkinsonism, akathisia and acute dystonia.

brand name

Kemadrin (Monarch).

General Description

Procyclidine hydrochloride,α-cyclohexyl-α-phenyl-1-pyrrolidinepropanolhydrochloride (Kemadrin), was introduced in 1956. Althoughit is an effective peripheral anticholinergic and, indeed, hasbeen used for peripheral effects similar to its methochloride(i.e., tricyclamol chloride), its clinical usefulness lies inits ability to relieve voluntary muscle spasticity by its centralaction. Therefore, it has been used with success in thetreatment of Parkinson syndrome. It is said to be as effectiveas trihexyphenidyl and is used to reduce muscle rigidityin postencephalitic, arteriosclerotic, and idiopathic types ofthe disease. Its effect on tremor is not predictable and probablyshould be supplemented by combination with othersimilar drugs.
The toxicity of the drug is low, but when the dosageof the drug is high, side effects are noticeable. At therapeuticdosage levels, dry mouth is the most common sideeffect. The same care should be exercised with this drugas with all other anticholinergics when it is administeredto patients with glaucoma, tachycardia, or prostatichypertrophy.

Biochem/physiol Actions

Procyclidine is a synthetic anti-cholinergic agent and atropine-like antispasmodic. It exhibits therapeutic effects against Parkinson′s disease and schizophrenia. Procyclidine acts as a muscarinic receptor antagonist. It also affects N-methyl-D-aspartate (NMDA) glutamine and nicotinic acetylcholine receptors to a lower extent.

Clinical Use

Control of extrapyramidal symptoms
Acute dystonias

Metabolism

When given orally about one fifth of the dose is known to be metabolised in the liver, principally by cytochrome P450 and then conjugated with glucuronic acid. Metabolites have been found in the urine.

PROCYCLIDINE HYDROCHLORIDE(1508-76-5)Related Product Information

• Pyridine hydrochloride
• Trimethylamine hydrochloride
• Betaine hydrochloride
• Methylamine hydrochloride
• tricyclamol chloride
• 1-PHENYL-1-HEPTANOL
• N-OCTYL PYRROLIDINE
• PROCYCLIDINE HYDROCHLORIDE
• 3-DIMETHYLAMINO-1-PHENYL-PROPAN-1-OL
• Cyclohexyl(phenyl)methanol
• procyclidine
• 3-AMINO-1-PHENYL-PROPAN-1-OL
• 1-PHENYL-3-(PYRROLIDIN-1-YL)PROPAN-1-OL
• Gamfexine