enbucrilate Chemical Properties

Boiling point:

bp1.8 68°

Density 

d20 0.989

vapor pressure 

1.3hPa at 20℃

refractive index 

n20D 1.4424; nD25 1.4410

Flash point:

closed cup: >176°F (>80°C)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Sparingly), Ethyl Acetate (Slightly)

form 

Oil

color 

Colourless

InChI

InChI=1S/C8H11NO2/c1-3-4-5-11-8(10)7(2)6-9/h2-5H2,1H3

InChIKey

JJJFUHOGVZWXNQ-UHFFFAOYSA-N

SMILES

C(OCCCC)(=O)C(C#N)=C

LogP

1.29 at 25℃ and pH7

Surface tension

34.28mN/m at 1g/L and 20℃

EPA Substance Registry System

Butyl 2-cyanoacrylate (6606-65-1)

enbucrilate Usage And Synthesis

Uses

Enbucrilate is bacteriostatic and its use is usually painless. It is used as an adhesive for lacerations of the skin, and in the treatment of bleeding from vascular structures.

Definition

ChEBI: Enbucrilate is a nitrile and an alpha,beta-unsaturated monocarboxylic acid.

Clinical Use

Enbucrilate injection of esophageal varices was first reported by Gotlib and Zimmermann in 1984 and has since been used in the acute treatment of bleeding esophageal varices in a few series, including randomized trials against band ligation for acute bleeding and for eradication of high-risk varices. Enbucrilate is often combined with lipiodol (lipid-soluble ethiodized oil) for injection of bleeding gastrointestinal ulcers; the advantage of this combination is slower polymerization of enbucrilate, with more accurate administration of the glue, but a potential disadvantage is a higher frequency of embolism, several cases of which have been reported. Overall, control of bleeding by using enbucrilate was found to be similar to band ligation, but rebleeding rates were higher. In addition, glue injection was found to be associated with sinus and fistula formation, in one case resulting in catastrophic bleeding. The higher complication rate may be explained by an increased risk of extravascular injection and attendant histotoxic reactions owing to the smaller lumen diameter.

enbucrilate(6606-65-1)Related Product Information

• Decamethylcyclopentasiloxane
• Butyl acrylate
• ETHYL 2-CYANOACRYLATE
• Flocculant
• 2-Ethylhexyl 2-cyano-5-phenyl-2,4-pentadienoate
• enbucrilate
• Octocrylene
• 2-ETHYLHEXYL ALPHA-CYANO-4-(3-METHYLOXAZOLIN-2-YLIDENE)CROTONATE
• 2-ETHYLHEXYL ALPHA-CYANO-3,4-DIMETHOXYCINNAMATE
• 2-ETHYLHEXYL ALPHA-CYANO-3,4-METHYLENEDIOXYCINNAMATE
• isoamyl 2-cyanoacrylate