4-Hydroxymethylbenzocyclobutene Chemical Properties

Boiling point:

266.3±9.0 °C(Predicted)

Density 

1.170±0.06 g/cm3(Predicted)

refractive index 

1.62

Flash point:

130.67ºC

storage temp. 

Sealed in dry,Room Temperature

pka

14.50±0.10(Predicted)

Appearance

Off-white to light yellow Solid

InChI

InChI=1S/C9H10O/c10-6-7-1-2-8-3-4-9(8)5-7/h1-2,5,10H,3-4,6H2

InChIKey

JJVAJBCHJBHRNT-UHFFFAOYSA-N

SMILES

C12C(CC1)=CC=C(CO)C=2

LogP

1.66270

Safety Information

HS Code 

2906290090

4-Hydroxymethylbenzocyclobutene Usage And Synthesis

Uses

4-Hydroxymethylbenzocyclobutene is a colorless liquid and can be used as an organic intermediate.

Preparation

The preparation of 4-hydroxymethylbenzocyclobutene: To a stirred solution of 1.32 g of 4-formylbenzocyclobutene in 15 mL of ethanol at room temperature is added 0.38 g of sodium borohydride. The reaction mixture is stirred for 2 h at room temperature. Ethanol is removed using a rotary evaporator and the residual material is diluted with 50 mL of water. The aqueous mixture is extracted with ethyl acetate. The ethyl acetate layer is washed with water and with saturated sodium chloride brine and dried over anhydrous magesium sulfate. The solution is filtered and solvent is removed from the filtrate. The yield of 4-hydroxymethylbenzocyclobutene is 1.27 g (95%, m.p. 70° C. from hexanes).

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