N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Chemical Properties

Melting point:

157 - 162°C

Density 

1?+-.0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

solubility 

Aqueous Acid (Slightly), Methanol (Slightly), Water (Slightly, Heated)

form 

Solid

pka

13.36±0.50(Predicted)

color 

White to Off-White

InChI

InChI=1S/C13H19N5/c1-9-3-5-14-7-11(9)18(2)13-10-4-6-15-12(10)16-8-17-13/h4,6,8-9,11,14H,3,5,7H2,1-2H3,(H,15,16,17)/t9-,11+/m1/s1

InChIKey

XRIARWQZLGCQDM-KOLCDFICSA-N

SMILES

C1=NC(N(C)[C@@H]2[C@H](C)CCNC2)=C2C=CNC2=N1

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Usage And Synthesis

Description

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is an important pharmaceutical intermediate that is a by-product of the preparation of tofacitinib. Tofacitinib belongs to a class of Janus kinase (JAK) inhibitors used in the treatment of rheumatoid arthritis and psoriatic arthritis.

Uses

N-Methyl-N-((3S,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, is an intermediate in the synthesis of (3S,4R)-Tofacitinib (T528010), an enantiopure stereoisomer of the drug, Janus kinase 3(Jak3) inhibitor (CP-690,550) that has been found to inhibit selected members of the STE7 and STE20 subfamily of kinases.

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(477600-74-1)Related Product Information

• Tofacitinib
• N-Methyl-N-((3S,4S)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine
• 3-Piperidinamine,4-methyl-1-(phenylmethyl)-,(3R,4R)-rel-
• methyl3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin -4-yl)amino)piperidin-1-yl)-3-oxopropanoate
• (3R,4S)-1-benzyl-N,4-dimethylpiperidin-3-amine
• (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
• Tofacitinib Impurity 6
• (3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile
• 3-((3R,4R)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanaMide
• 3-((3R,4R)-3-((2-chloro-7H-pyrrolo[2,3-d]pyriMidin-4-yl)(Methyl)aMino)-4-Methylpiperidin-1-yl)-3-oxopropanenitrile
• 3-PiperidinaMine, 1-acetyl-N,4-diMethyl-N-1H-pyrrolo[2,3-d]pyriMidin-4-yl-, (3R,4R)- (9CI)
• 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
• 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE
• N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-
• 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE
• (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
• Tofacitinib Impurity T