MUPIROCIN CALCIUM, REFERENCE SPECTRUM EP STANDARD
MUPIROCIN CALCIUM, REFERENCE SPECTRUM EP STANDARD Basic information
- Product Name:
- MUPIROCIN CALCIUM, REFERENCE SPECTRUM EP STANDARD
- Synonyms:
-
- MUPIROCIN CALCIUM, REFERENCE SPECTRUM EP STANDARD
- Calcium mupirocin dihydrate
- L-talo-Non-2-enonic acid, 5,9-anhydro-2,3,4,8-tetradeoxy-8-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-3-methyl-, 8-carboxyoctyl ester, calcium salt (2:1), dihydrate, [2E,8[2S,3S(1S,2S)]]- (9CI)
- mupirocin calcium hydrate
- Calcium 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoate dihydrate
- Mupirocin calcium dihydrate
- Mupirocin Calcium (200 mg)
- 5,9-ANHYDRO-2,3,4,8-TETRADEOXY-8-[[3-(2-HYDROXY-1-METHYLPROPYL)OXIRANYL]METHYL]-3-METHYL-[2E,8[2S,3S(1S,2S)]]-L-TALONONO
- CAS:
- 115074-43-6
- MF:
- C52H86CaO18.2H2O
- MW:
- 1075.34
- EINECS:
- 200-158-5
- Product Categories:
-
- API
- Mol File:
- 115074-43-6.mol
MUPIROCIN CALCIUM, REFERENCE SPECTRUM EP STANDARD Chemical Properties
- Melting point:
- 132-139 °C
- storage temp.
- Store at -20°C
- solubility
- Very slightly soluble in water, sparingly soluble in anhydrous ethanol and in methylene chloride.
- form
- Solid
- color
- White to Off-White
- Water Solubility
- Water: 6 mg/mL (5.58 mM)
- InChIKey
- DDHVILIIHBIMQU-UGPPHRKUNA-L
MUPIROCIN CALCIUM, REFERENCE SPECTRUM EP STANDARD Usage And Synthesis
Chemical Properties
White or almost white powder.
Uses
Mupirocin (M794000), is a major component of the pseudomonic acid, an antibiotic complex produced by Pseudomonas fluorescens NCIB 10586. Topical antibacterial.
Uses
Antibacterial (topical).
Definition
ChEBI: Mupirocin calcium hydrate is a hydrate that is the dihydrate form of mupirocin calcium. It is an antibacterial drug used for the treatment of skin infections such as impetigo caused by Staphylococcus aureus and meticillin-resistant Staphylococcus aureus (MRSA). It has a role as an antibacterial drug, a protein synthesis inhibitor and an antiinfective agent. It contains a mupirocin calcium (anhydrous).
brand name
Bactroban (GlaxoSmithKline).
in vivo
MRSA: Meticillin-resistant Staphylococcus aureus
Mupirocin (BRL-4910A, Pseudomonic acid) calcium is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A[1].
Mupirocin calcium (2% ointment; external administration; twice daily; 3-6 d) decreases the total bacterial loads in the skin lesions with either topical treatment[3].
Mupirocin calcium (2% ointment; external administration; 4 d) alleviates MRSA-infected pressure ulcers in mice[4].
Mupirocin calcium (100 mg/mL; s.c.; 7 d) exerts prevention efficacy against vascular prosthetic graft infection due to Staphylococcus epidermidis[5].
| Animal Model: | MRSA skin infection model in mice (10-12 weeks old)[3] |
| Dosage: | 2% ointment |
| Administration: | External administration; twice daily; 3-6 days |
| Result: | Reduced the total bacterial loads in the skin lesions, and decreased by 2.0, 5.1 log10 CFU on day 3 and 6, respectively. |
| Animal Model: | Diabetic pressure ulcer mouse model (33.2-39.2 g)[4] |
| Dosage: | 2% ointment |
| Administration: | External administration; 4 days |
| Result: | Resulted less superficial mats of bacterial colonies, and improved histopathology evaluation. |
| Animal Model: | Adult male Wistar rats (weight 275-325 g)[5] |
| Dosage: | Impregnated with 100 μg of mupirocin/mL; segments:1.5 cm *1 cm2 |
| Administration: | Subcutaneous implantation; 7 days |
| Result: | Resulted in preventing S. epidermidis infection of the graft in a rat model with spontaneously bound to collagen-sealed Dacron grafts. |
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