Polymyxin B Chemical Properties

alpha 

5461 -106.3° (1N HCl)

form 

Solid

color 

White to light yellow

Polymyxin B Usage And Synthesis

Description

Polymyxin B was isolated by Wellcome Research Laboratories, in 1949, from the mixture of polymyxins A, B, C, and D produced byBacillus polymyxa. It was later separated into the major component, B1, and the minor component, B2. Polymyxin B is a basic polypeptide and shows strong activity against gram-negative bacteria, but its activity against gram-positive bacteria, Mycobacterium, and fungi is weak. Because of its toxicity, it is used carefully by intramuscular injection for resistant Pseudomonas aeruginosa infections, e.g., sepsis. Polymyxin B is used orally to sterilize the gut in leukemic patients, intraspinally for meningitis, or topically.

Uses

Antibacterial Aerosporin.

Definition

ChEBI: A polymyxin having a 6-methylheptanoyl group at the amino terminus.

brand name

(GlaxoSmithKline); Poly-Rx (X Gen).

Contact allergens

Active against Gram-negative bacteria, Polymyxin B is a mixture of Polymyxin B1 and B2. Sensitization occurs by topical, ophthalmic, and otic preparations. Cosensitization is frequent with other topical antibiotics like neomycin or bacitracin.

Polymyxin B (1404-26-8)Related Product Information

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• Polymyxin B sulfate