4-METHYLPYRAZOLE HYDROCHLORIDE
4-METHYLPYRAZOLE HYDROCHLORIDE Basic information
- Product Name:
- 4-METHYLPYRAZOLE HYDROCHLORIDE
- Synonyms:
-
- FOMEPIZOLE HYDROCHLORIDE
- 4-METHYLPYRAZOLE HYDROCHLORIDE
- Fomepizole/FomepizolechlorideHCl
- 4-Methyl-1H-pyrazole hydrochloride
- 4-Methylpyrazole hydrochloride alcohol dehydrogenase inhibitor
- CAS:
- 56010-88-9
- MF:
- C4H7ClN2
- MW:
- 118.56
- Mol File:
- 56010-88-9.mol
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4-METHYLPYRAZOLE HYDROCHLORIDE Chemical Properties
- Melting point:
- 157-159 °C
- storage temp.
- 2-8°C
- solubility
- methanol: 100mg/mL, clear, colorless to yellow
- form
- powder
- color
- Purple to purplish red
- biological source
- synthetic (organic)
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MSDS
- Language:English Provider:SigmaAldrich
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4-METHYLPYRAZOLE HYDROCHLORIDE Usage And Synthesis
Uses
4-Methylpyrazole hydrochloride has been used:
- as a cytochrome P450 2E1 inhibitor
- as cytochrome P450 2E1 and alcohol dehydrogenase inhibitor in 1C11 neural progenitor cells
- to inhibit ethanol oxidation in VL-17A cells expressing alcohol dehydrogenase and HepG2 cells
Biochem/physiol Actions
4-Methylpyrazole (4MP) inhibits ethanol oxidation in liver microsomes. It also blocks the c-Jun N-terminal kinase (JNK) activation in in vitro liver injury models.
in vivo
Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 mice[4]
| Animal Model: | Male CD-1 mice weighing 18-25 g[4] |
| Dosage: | 25 mg/kg |
| Administration: | IP; single dose |
| Result: | Decreased the dose of ethanol (1-5 g/kg; IP) at which 50% of the animals failed a particular outcome test (toxic dose 50; TD50). |
IC 50
CYP2E1
4-METHYLPYRAZOLE HYDROCHLORIDESupplier
Tianjin heowns Biochemical Technology Co., Ltd.
- Tel
- 400 638 7771
- sales@heowns.com
Spectrum Chemical Manufacturing Corp.
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- marketing_china@spectrumchemical.com
SynAsst Chemical.
- Tel
- 021-60343070
Guangzhou Isun Pharmaceutical Co., Ltd
- Tel
- 020-39119399 18927568969
- isunpharm@qq.com
Sigma-Aldrich
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
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4-METHYLPYRAZOLE HYDROCHLORIDE(56010-88-9)Related Product Information
- 5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE
- 2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE
- 5-CHLORO-3-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
- 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXALDEHYDE
- (-)-QUINPIROLE HYDROCHLORIDE
- 1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE
- Dichlorosulfophenyl-3-methylpyrazolone
- 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carbaldehyde
- 1-(4-CHLOROPHENYL)-5-PROPYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
- 4-Methylpyrazole
- ETHYL 1-(4-CHLOROPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE
- 2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLIC ACID
- 1-(3-CHLOROPHENYL)-5-(1H-PYRROL-1-YL)-1H-PYRAZOLE-4-CARBONITRILE
- 5-AMINO-1-(3-CHLORO-4-FLUOROPHENYL)-4-CYANOPYRAZOLE
- 2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLIC ACID HYDRAZIDE
- 4-METHYLPYRAZOLE HYDROCHLORIDE
- 5-AMINO-1-(2,4-DICHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE
- 5-CHLORO-3-[2-(DIMETHYLAMINO)-1-FORMYLVINYL]-1-PHENYL-1H-PYRAZOLE-4-CARBOXALDEHYDE