4-METHYLPYRAZOLE HYDROCHLORIDE Chemical Properties

Melting point:

157-159 °C

storage temp. 

2-8°C

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

4-METHYLPYRAZOLE HYDROCHLORIDE Usage And Synthesis

Uses

4-Methylpyrazole hydrochloride has been used:

• as a cytochrome P450 2E1 inhibitor
• as cytochrome P450 2E1 and alcohol dehydrogenase inhibitor in 1C11 neural progenitor cells
• to inhibit ethanol oxidation in VL-17A cells expressing alcohol dehydrogenase and HepG2 cells

Biochem/physiol Actions

4-Methylpyrazole (4MP) inhibits ethanol oxidation in liver microsomes. It also blocks the c-Jun N-terminal kinase (JNK) activation in in vitro liver injury models.

4-METHYLPYRAZOLE HYDROCHLORIDE(56010-88-9)Related Product Information

• 5-AMINO-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE
• 2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE
• 5-CHLORO-3-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
• 5-CHLORO-1-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXALDEHYDE
• (-)-QUINPIROLE HYDROCHLORIDE
• 1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE
• Dichlorosulfophenyl-3-methylpyrazolone
• 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carbaldehyde
• 1-(4-CHLOROPHENYL)-5-PROPYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
• 4-Methylpyrazole
• ETHYL 1-(4-CHLOROPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE
• 2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLIC ACID
• 1-(3-CHLOROPHENYL)-5-(1H-PYRROL-1-YL)-1H-PYRAZOLE-4-CARBONITRILE
• 5-AMINO-1-(3-CHLORO-4-FLUOROPHENYL)-4-CYANOPYRAZOLE
• 2-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLIC ACID HYDRAZIDE
• 4-METHYLPYRAZOLE HYDROCHLORIDE
• 5-AMINO-1-(2,4-DICHLOROPHENYL)-1H-PYRAZOLE-4-CARBONITRILE
• 5-CHLORO-3-[2-(DIMETHYLAMINO)-1-FORMYLVINYL]-1-PHENYL-1H-PYRAZOLE-4-CARBOXALDEHYDE