1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Chemical Properties

Melting point:

133.5-136 °C(lit.)

Boiling point:

215-220 °C50 mm Hg(lit.)

Density 

1.097

vapor pressure 

0.004Pa at 20℃

refractive index 

1.4540 (estimate)

Flash point:

166℃

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

powder to crystal

pka

14.66±0.10(Predicted)

color 

White to Almost white

Water Solubility 

Soluble in water.

InChIKey

VARKIGWTYBUWNT-UHFFFAOYSA-N

LogP

-1.92 at 20℃

CAS DataBase Reference

122-96-3(CAS DataBase Reference)

EPA Substance Registry System

1,4-Piperazinediethanol (122-96-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26

WGK Germany 

3

RTECS 

TL3675000

TSCA 

Yes

HS Code 

2933.59.9500

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

1,4-Piperazinediethanol is useful in the synthesis of salt-inducible kinase inhibitors for the treatment of diseases.

Flammability and Explosibility

Not classified

Synthesis

The general procedure for the synthesis of N,N'-bis(2-hydroxyethyl)piperazine from diethanolamine is as follows: Example 2: Preparation of 1,4-bis(hydroxyethyl)piperazine from diethanolamine under solvent-free conditions Operational steps: 1. 100 g of diethanolamine (II) and 10 g of Catalyst A were added in the same reaction setup described in Example 1 . 2. Upon completion of the reaction, the reaction product was detected by gas chromatography analysis (GC column: 30m RTX Amin). 3. The analytical results showed that the content of 1,4-bis(hydroxyethyl)piperazine in the reaction product was 79% under the condition of complete conversion of diethanolamine.

References

[1] Patent: US2012/108816, 2012, A1. Location in patent: Page/Page column 6
[2] Patent: US2868791, 1954,
[3] Patent: US2636033, 1950,
[4] Patent: DE917784, 1952,
[5] Patent: DE917784, 1952,

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE(122-96-3)Related Product Information

• Simetride
• 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE
• Piperazine-N,N'-bis(2-hydroxypropanesulphonic acid) disodium salt
• POPSO
• HEPPSO sodium
• nafiverine
• Piperazine-N,N'-bis(2-hydroxypropanesulfonic acid) sesquisodium salt
• HEPPSO
• zipeprol
• gypsetin
• Aranotine
• Apicycline
• Febuverine
• 6(1H)-Purinone, 2,3-dihydro-3,7-dimethyl-8-(4-(2-hydroxyethyl)piperazi nyl)-1-(2-hydroxy-3-(4-(2-hydroxyethyl)piperazinyl)propyl)-
• 6(1H)-Purinone, 2,3-dihydro-3,7-dimethyl-1-(2-hydroxy-3-(4-(2-hydroxye thyl)piperazinyl)propyl)-
• 1-(4-[2-HYDROXY-3-(1,3,6-TRIBROMO-9H-CARBAZOL-9-YL)PROPYL]PIPERAZINO)-3-(1,3,6-TRIBROMO-9H-CARBAZOL-9-YL)PROPAN-2-OL DIHYDROCHLORIDE
• 1,4-BIS(2-HYDROXYPROPYL)-2-METHYLPIPERAZINE
• 2-PHENOXY-1-[4-(2-PHENOXY-ACETYL)-PIPERAZIN-1-YL]-ETHANONE