osthenol Chemical Properties

Melting point:

89-91 °C

Boiling point:

422.8±45.0 °C(Predicted)

Density 

1.203±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

pka

8.45±0.20(Predicted)

LogP

3.342 (est)

osthenol Usage And Synthesis

Chemical Properties

Soluble in methanol, ethanol, DMSO and other organic solvents, derived from Rhizoma et Radix Notopterygii.

Definition

ChEBI: Osthenol is a hydroxycoumarin that is umbelliferone in which the hydrogen at position 8 has been replaced by a prenyl group. It has a role as a plant metabolite and an antifungal agent. It is functionally related to an umbelliferone.

Biological Activity

Ostenol (Ostenol), a preacylated coumarin isolated from the dried roots of Ostonia, is a reversible, selective and competitive inhibitor of human monoamine oxidase-A (hMAO-A) (Ki=0.26 μM) . Oshenol has a potential selective inhibitory effect on recombinant hMAO-A with IC50 of 0.74 μM, showing a high selectivity index for hMAO-A and hMAO-B.

osthenol(484-14-0)Related Product Information

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