5-Amino-1-methylpyrazole-4-carboxamide Chemical Properties

Melting point:

224-226°C

Boiling point:

355.1±22.0 °C(Predicted)

Density 

1.56±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

15.26±0.50(Predicted)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

36/37/38-25

Safety Statements 

26-36/37/39-24/25-22-45

RIDADR 

UN 2811 6.1 / PGIII

HazardClass 

IRRITANT

HS Code 

2933199090

5-Amino-1-methylpyrazole-4-carboxamide Usage And Synthesis

Synthesis

The general procedure for the synthesis of 5-amino-1-methyl-1H-pyrazole-4-carboxamide from 1-methyl-4-cyano-5-amino-1,2-pyrazole was carried out as follows: a mixture of 1-methyl-4-cyano-5-amino-1,2-pyrazole (0.11 mol) and concentrated sulfuric acid (30 mL, 0.6 mol) was stirred for 1 h at room temperature. Upon completion of the reaction, the mixture was slowly poured into ice water and the pH was adjusted to 8 with 50% aqueous ammonium hydroxide under ice bath conditions.Subsequently, the precipitated solid product was filtered and washed with cold water to give the final 5-amino-1-methyl-1H-pyrazole-4-carboxamide (13.5 g, 91% yield).

References

[1] Patent: WO2009/97446, 2009, A1. Location in patent: Page/Page column 64
[2] Patent: WO2009/97446, 2009, A1. Location in patent: Page/Page column 64
[3] Journal of Organic Chemistry, 1956, vol. 21, p. 1240,1242
[4] Patent: EP2025678, 2009, A1. Location in patent: Page/Page column 18-19

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