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4-THIOURIDINE

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4-THIOURIDINE Basic information

Product Name:
4-THIOURIDINE
Synonyms:
  • 1-((2R,3R,4S,5R)
  • -4-thioxo-3,4-dihydropyrimidin-2(1H)
  • THIOURIDINE, 4-
  • 4-THIOURIDINE
  • thiouridine
  • 4-thiouridineapprox.
  • 4-Thio-D-uridine
  • 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-4-thioxo-3,4-dihydropyriMidin-2(1H)-one
CAS:
13957-31-8
MF:
C9H12N2O5S
MW:
260.27
EINECS:
237-735-3
Product Categories:
  • Biochemicals and Reagents
  • Nucleoside Analogs
  • Nucleosides, Nucleotides, Oligonucleotides
  • Bases & Related Reagents
  • Nucleotides
  • Sulfur & Selenium Compounds
Mol File:
13957-31-8.mol
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4-THIOURIDINE Chemical Properties

Melting point:
139-140℃ (ethanol )
Density 
1.72±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
pka
4.75±0.20(Predicted)
form 
crystalline
color 
light yellow
PH
8.2
Water Solubility 
Soluble in water (20 mg/ml), and methanol (10 mg/ml).
λmax
245,331 (pH 6.5);316 (pH 12)
InChIKey
ZLOIGESWDJYCTF-XVFCMESISA-N
CAS DataBase Reference
13957-31-8(CAS DataBase Reference)
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29349990

MSDS

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4-THIOURIDINE Usage And Synthesis

Description

4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.

Uses

Nucleotide analogue, essential for cell growth in certain bacterial species. This compound is also able to chelate with certain metal ions, and in tRNA it can act as a built-in antiphotomutagenic agent that protects Escherichia coli cells against mutagenesis.

Uses

4-Thiouridine is a constituent of several transfer RNA's. 4-Thiouridine is a thionucleobase used as an antisense agent. Widely used for RNA analysis including RNA-RNA cross coupling and RNA labelling. 4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases. 4-Thio Uridine is typically used to modify oligos slated for RNA, or RNA-protein, structural studies. A 4-thio-rU modified RNA pentamer was used to study the effect of this modification on codon-anticodon interaction when it is in the wobble position of tRNA.

Definition

ChEBI: A thiouridine in which the oxygen replaced by sulfur is that at C-4.

General Description

4-Thiouridine is a photoreactive uridine analog.

Biochem/physiol Actions

4-Thiouridine plays a role in assessing nascent RNA synthesis. It also enhances site-specific crosslinking. 4-Thiouridine also acts as a photoaffinity probe due to its stability even while lacking specific photoactivation. It can also be incorporated into RNAs.

storage

Store at -20°C

4-THIOURIDINESupplier

Zhengzhou Granlen Sciences, ltd. Gold
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0371-85513397 +86-18610099868;
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19308655899
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0551-65171243 13856024262
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821-50328103-801 18930552037
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