5-CHLOROBENZOXAZOLE Chemical Properties

Melting point:

42-46 °C

Boiling point:

226.3±13.0℃ (760 torr)

Density 

1.377±0.06 g/cm3 (20 ºC 760 Torr)

refractive index 

1.5618 (estimate)

Flash point:

90.7±19.8℃

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to lump

pka

-0.85±0.10(Predicted)

color 

White to Orange to Green

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26

WGK Germany 

3

RTECS 

DM4690000

HS Code 

29349990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

5-CHLOROBENZOXAZOLE Usage And Synthesis

Chemical Properties

yellowish-orange crystalline chunks

Synthesis

General method: triethyl orthoformate (1.1 mmol) was mixed with 4-chloro-2-aminophenol (1 mmol) and p-toluenesulfonic acid (TSA, 1 mol%) was added as a catalyst. The reaction mixture was stirred at 80-90 °C until the reaction was complete (monitored by TLC) according to the reaction conditions shown in Table 4. After completion of the reaction, the reaction mixture was diluted with chloroform (10 mL) and the catalyst was removed by filtration. Finally, the product 5-chlorobenzazole was purified by column chromatography.

References

[1] Comptes Rendus Chimie, 2013, vol. 16, # 11, p. 1029 - 1034
[2] Combinatorial Chemistry and High Throughput Screening, 2013, vol. 16, # 8, p. 618 - 627
[3] Monatshefte fur Chemie, 2007, vol. 138, # 7, p. 663 - 667
[4] Angewandte Chemie - International Edition, 2012, vol. 51, # 19, p. 4666 - 4670
[5] Monatshefte fur Chemie, 2011, vol. 142, # 1, p. 87 - 91

5-CHLOROBENZOXAZOLE(17200-29-2)Related Product Information

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