1-(2,4-DIHYDROXY-PHENYL)-2-(4-HYDROXY-PHENYL)-ETHANONE Chemical Properties

Melting point:

192 °C

Boiling point:

499.0±14.0 °C(Predicted)

Density 

1.380

storage temp. 

Inert atmosphere,Room Temperature

form 

Solid

pka

7.62±0.35(Predicted)

Appearance

White to off-white Solid

InChI

InChI=1S/C14H12O4/c15-10-3-1-9(2-4-10)7-13(17)12-6-5-11(16)8-14(12)18/h1-6,8,15-16,18H,7H2

InChIKey

KLFCJXAPIFIIFR-UHFFFAOYSA-N

SMILES

C(=O)(C1=CC=C(O)C=C1O)CC1=CC=C(O)C=C1

Safety Information

Hazard Codes 

Xi

Risk Statements 

43

Safety Statements 

36/37

1-(2,4-DIHYDROXY-PHENYL)-2-(4-HYDROXY-PHENYL)-ETHANONE Usage And Synthesis

Preparation

Preparation by reaction of p-hydroxyphenylacetic acid with resorcinol in the presence of boron trifluoride etherate under argon on a water bath for 1 h (98%), at 100° for 1 h (70%) or for 15 min (40%).

Synthesis

Step 1: Synthesis of 1-(2,4-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethanone Resorcinol (62.000 g, 563.1 mmol, 1.0 eq.) and 4-hydroxyphenylacetic acid (94.237 g, 619.4 mmol, 1.1 eq.) were added to a 2 L three-necked, round-bottomed flask fitted with a mechanical stirring paddle, pressure-balanced dosing funnel, thermometer, and a heating jacket under nitrogen protection. Toluene (350 mL) was added to form a suspension. Boron trifluoride ether compound (198.201 mL, 1578.0 mmol, 2.8 eq.) was slowly added dropwise through the dosing funnel at a controlled rate of 3-4 mL/min while stirring the reaction mixture at 150 rpm. During the reaction, the internal temperature was gradually increased to 100°C and the color of the solution gradually changed from yellow to dark red. After dropwise addition, the addition funnel was removed, the condenser was replaced, and the reaction was continued with stirring at 108°C for 1.5 h. The reaction was completed by HPLC analysis. The completion of the reaction was confirmed by HPLC analysis. The heating was stopped, the reaction mixture was cooled to room temperature and left to stratify. A 12% aqueous sodium acetate solution (41 g dissolved in 336 mL of water) was added slowly with stirring and stirring was continued for 16 hours. The precipitated solid was collected by filtration in a sintered glass funnel and dried under vacuum for 16 h to give a white powdery product (119.67 g, 87.0% yield).

References

[1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991, # 12, p. 3005 - 3008
[2] Journal of Organic Chemistry, 2000, vol. 65, # 8, p. 2305 - 2308
[3] Journal of Agricultural and Food Chemistry, 1994, vol. 42, # 9, p. 1869 - 1871
[4] Tetrahedron Letters, 2006, vol. 47, # 47, p. 8375 - 8378
[5] Patent: WO2013/90921, 2013, A1. Location in patent: Paragraph 00165

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