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6,7,4'-Trihydroxyisoflavone

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6,7,4'-Trihydroxyisoflavone Basic information

Product Name:
6,7,4'-Trihydroxyisoflavone
Synonyms:
  • TRIHYDROXYISOFLAVONE, 4',6,7-
  • DEMETHYLTEXASIN
  • 6,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
  • TRIHYDROXYISOFLAVONE, 4',6,7-(RG)
  • DESMETHYLGLYCITEIN (4',6,7-TRIHYDROXYISOFLAVONE)
  • 6,7-Dihydroxy-3-(4-hydroxyphenyl)
  • Desmethylglycitein
  • 4H-1-Benzopyran-4-one, 6,7-dihydroxy-3-(4-hydroxyphenyl)-
CAS:
17817-31-1
MF:
C15H10O5
MW:
270.24
Product Categories:
  • Iso-Flavones
Mol File:
17817-31-1.mol
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6,7,4'-Trihydroxyisoflavone Chemical Properties

Melting point:
>280℃
Boiling point:
587.1±50.0 °C(Predicted)
Density 
1.548±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
soluble in Dimethylformamide
form 
powder to crystal
pka
6.85±0.20(Predicted)
color 
Light yellow to Brown to Dark green
biological source
synthetic
LogP
2.170 (est)
CAS DataBase Reference
17817-31-1(CAS DataBase Reference)
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
3
F 
10
HS Code 
2914.69.9000

MSDS

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6,7,4'-Trihydroxyisoflavone Usage And Synthesis

Uses

4'',?6,?7-?Trihydroxyisoflavone is an isoflavone modulator of adenosine-monophosphate-activated protein kinase.

Definition

ChEBI: A hydroxyisoflavone that is daidzein bearing an additional hydroxy substituent at position 6.

in vivo

Desmethylglycitein (4',6,7-Trihydroxyisoflavone) (intraperitoneally injection; 5 or 25 mg/kg; once daily; 20 days) suppresses tumor development in mice and serves as an effective anticancer treatment with the potential to inhibit or delay the tumorigenicity of HCT-116 cells in an in vivo system[1].

Animal Model:Female athymic nude mice subcutaneously injected with HCT-116 cells[1]
Dosage:5 or 25 mg/kg
Administration:Intraperitoneally injection; 5 or 25 mg/kg; once daily; 20 days
Result:Decreased tumor growth, volume and weight of HCT-116 xenografts.

IC 50

CDK1; CDK2; PKC

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