Brinzolamide-d5 Chemical Properties

storage temp. 

Refrigerator

solubility 

Ethanol

form 

Solid

color 

Crystalline

Brinzolamide-d5 Usage And Synthesis

Description

Brinzolamide-d₅ is intended for use as an internal standard for the quantification of brinzolamide by GC- or LC-MS. Brinzolamide is a potent inhibitor of carbonic anhydrase II (CAII) and CAIV (IC₅₀s = 3.19 and 45.3 nM, respectively). It is selective for CAII and CAIV over CAI (IC₅₀ = ~1,365 nM). Brinzolamide (30 mg/kg) reduces intestinal charcoal meal progression by 44% and prolongs pentobarbital sodium-induced sleep time by 35% in mice. Topical administration of brinzolamide (0.25, 0.5, and 1 mg/eye) reduces intraocular pressure in a rabbit model of spontaneous ocular hypertension. It also reduces intraocular pressure in a cynomolgus monkey model of argon laser trabeculoplasty-induced ocular hypertension. Formulations containing brinzolamide have been used in the treatment of glaucoma and ocular hypertension.

Chemical Properties

Crystalline Solid

Uses

Carbonic anhydrase inhibitor. Antiglaucoma agent.

Brinzolamide-d5(1217651-02-9)Related Product Information

• N-DESMETHYLDILTIAZEM, HYDROCHLORIDE
• DESACETYL DILTIAZEM HCL
• N-Desethyl Brinzolamide
• Diltiazem-d6
• Diltiazem N-Oxide
• Brinzolamide
• Diltiazem Impurity 5
• BrinzolaMide iMpurity
• Diltiazem impurity
• (S)-3,4-Dihydro-4-hydroxy-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
• Diltiazem Impurity 4
• Diltiazem hydrochloride
• Deacetyl Diltiazem N-Oxide
• N,N,O-Tridesmethyl Diltiazem
• Deacetyldiltiazem
• (2R-cis)-3-acetoxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one monohydrochloride
• Diltiazem Impurity 8
• Diltiazem Impurity 3