Bisandrographolide A Chemical Properties

Boiling point:

832.6±65.0 °C(Predicted)

Density 

1.23±0.1 g/cm3(Predicted)

pka

14.82±0.70(Predicted)

Bisandrographolide A Usage And Synthesis

Uses

Bisandrographolide A (BAA) activates TRPV4 channel with an EC50 of 790-950 nM. Bisandrographolide A can bind to CD81 and suppress its function. Bisandrographolide A is an anti-inflammatory, immunostimulant, and antihypertensive compound[1][2].

References

[1] Yue GG, et al. Identification of active components in Andrographis paniculata targeting on CD81 in esophageal cancer in vitro and in vivo. Phytomedicine. 2022 Jul 20;102:154183. DOI:10.1016/j.phymed.2022.154183
[2] Vriens J, et al. Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4. J Biol Chem. 2007 Apr 27;282(17):12796-803. DOI:10.1074/jbc.M610485200

Bisandrographolide A(160498-00-0)Related Product Information

• Andrographolide
• 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one
• alpha-Cyperone
• beta-Sitosterol
• alpha-Terpineol
• Hydroxyecdysone
• Artemether
• MOSLOFLAVONE
• hydroxygenkwanin
• beta-Eudesmol
• (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one
• Herba Andrographis