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DESIPRAMINE

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DESIPRAMINE Basic information

Product Name:
DESIPRAMINE
Synonyms:
  • TIMTEC-BB SBB002569
  • N-[3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)PROPYL]-N-METHYLAMINE HYDROCHLORIDE
  • DESIPRAMINE
  • AURORA KA-7618
  • 10,11-Dihydro-5-(3-methylaminopropyl)-5H-dibenz(b,f)azepine
  • 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methyl-1-propanamine
  • 5H-Dibenz[b,f]azepine, 10,11-dihydro-5-[3-(methylamino)propyl]-
  • 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N-methyl-
CAS:
50-47-5
MF:
C18H22N2
MW:
266.38
EINECS:
200-040-0
Mol File:
50-47-5.mol
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DESIPRAMINE Chemical Properties

Melting point:
212°C
Boiling point:
bp0.02 172-174°
Density 
0.9934 (rough estimate)
refractive index 
1.5200 (estimate)
pka
pKa 10.21(-)(H2O t=20) (Uncertain)
form 
powder
color 
white
EPA Substance Registry System
Desipramine (50-47-5)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
WGK Germany 
3
Hazardous Substances Data
50-47-5(Hazardous Substances Data)

MSDS

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DESIPRAMINE Usage And Synthesis

Originator

Pertofran,Geigy,UK,1963

Uses

Desipramine is used for depression of various etiology and in particular for endogenous depression.

Uses

Antidepressant.

Definition

ChEBI: A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.

Manufacturing Process

Oxidative coupling of o-nitrotoluene gives 4,4'-dinitrodibenzyl which is reduced with hydrogen to the diamine. The diamine is pyrolyzed to give dihydrobenzazepine. This is reacted with N-(3-chloropropyl)-Nmethylbenzamine to give N-benzyldesipramine. This is debenzylated by reductive cleavage and then reacted with HCl.

brand name

Norpramin (Sanofi Aventis); Pertofrane (Sanofi Aventis).

Therapeutic Function

Psychostimulant

Mechanism of action

Its antidepressant effect results from increases in the level of NE in CNS synapses, and long-term administration causes a downregulation of α1-adrenoceptors and desensitization of presynaptic α2-receptors, equilibrating the noradrenergic system and, thus, correcting the dysregulated output of depressed patients. The SSRIs do not produce this effect. Desipramine also downregulates the NET, but not the 5-SERT . Substantial loss of NE transporter–binding sites takes 15 days to occur and is accompanied by a marked reduction of NET function in vivo. Desipramine has weak effects on 5-HT reuptake.

Synthesis

Desipramine, 10,11-dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f] azepine (7.1.13), differs from imipramine in that it contains only one methyl group on the nitrogen atom of the propylamine side chain. The suggested methods of desipramine synthesis are very simple, and the difference lies only in the manner in which the secondary methylamine group is introduced into the structure of the drug.
The first way of synthesis is by the alkylation of 10,11-dihydro-5H-dibenz[b,f]azepine using 1-bromo-3-chloropropane in the presence of sodium amide into a chloro derivative (7.1.12) and the subsequent reaction of this with methylamine, giving desipramine (7.1.13) [18–20].

Finally, a second way of synthesis is from imipramine (7.1.1), which undergoes demethylation by successive reaction with ethyl chloroformate, giving 5-[3-(N-carbethoxy-N-methyl)aminopropyl]-10,11-dihydro-5H-dibenz[b,f]azepine (7.1.15), the alkaline hydrolysis of which leads to desipramine (7.1.13) [23,24].

Metabolism

Desipramine is a dihydrodibenzazepine secondary amine TCA that also is the active metabolite of imipramine. Desipramine appears to have a bioavailability comparable to the other secondary TCAs. Desipramine is distributed into milk in concentrations similar to those present at steady state in maternal plasma. This drug is metabolized primarily by CYP2D6 to its 2-hydroxy metabolite and by CYP1A2 and CYP2C19 to its N-demethylated (primary amine) metabolite . Desipramine exhibits a greater potency and selectivity for the NET than the other secondary TCAs do.

DESIPRAMINESupplier

LGM Pharma
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