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Antidepressants, Antimanics drugs

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Manic depressive disorder, also known as affective disorders, is a kind of mental illness with its symptoms being emotional pathological changes. Manic-depressive disorder is characterized by repeated episodes of either manic or depressive episodes (single phase), or alternatively both of episodes (bipolar). The cause may be related to the brain monoamine dysfunction. However, the 5 - HT deficiency is the common biochemical basis. On this basis, upon NA (norepinephrine) hyperactivity, patients exhibits manic performance. Upon pathogenesis, patients are characterized by high mood, quick thinking and increased activities. NA dysfunction is manifested as depression. The patients will exhibit depression with reduced speech, reduced mental activity, bradykinesia and often self-blame and even attempt to suicide. The treatment of this disease is mainly symptomatic treatment with the main drugs being divided into antidepressant and anti-mania drugs. Commonly used antidepressants are tricyclic tetracyclines, including imipramine, desipramine, doxepin, amitriptyline, mianserin and maprotiline, etc. The major difference in the chemical structure of them with phenothiazine drugs is the substitution of the S atom with -CH2-CH2-.

These drugs are mainly used for the treatment of various types of depression. It has better efficacy in the treatment of the endogenous, reactive and menopausal depression, while being less effective in the treatment of the depression of schizophrenia. The most common adverse reactions exhibits atropine-like behavior such as dry mouth, constipation, blurred vision, palpitations and so on. A typical anti-mania agent is a lithium formulation. Lithiuim salt in treatment amount had almost little effect on the mental activity of normal people, but having significant effect on the mania patients, restoring the speech, behavior of patients to normal condition. Experiments have shown that lithium can inhibit the NA and DA release of brain while boosting its reuptake, causing the decrease concentration of NA in the synaptic cleft and resulting in anti-manic effect. There are many adverse reactions of lithium salt and the adverse reactions have individual differences. Other drugs such as chlorpromazine, haloperidol and anti-epileptic drug carbamazepine are also effective against mania.

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Structure:
Chemical Name:
Citalopram hydrobromide
CAS:
59729-32-7
MF:
C20H22BrFN2O
Structure:
Chemical Name:
Yohimbine hydrochloride
CAS:
65-19-0
MF:
C21H27ClN2O3
Structure:
Chemical Name:
Escitalopram oxalate
CAS:
219861-08-2
MF:
C22H23FN2O5
Structure:
Chemical Name:
Venlafaxine
CAS:
93413-69-5
MF:
C17H27NO2
Structure:
Chemical Name:
4-Chlorobutyl methyl ether
CAS:
17913-18-7
MF:
C5H11ClO
Structure:
Chemical Name:
5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone
CAS:
61718-80-7
MF:
C13H15F3O2
Structure:
Chemical Name:
AGOMELATINE
CAS:
138112-76-2
MF:
C15H17NO2
Structure:
Chemical Name:
Sertraline hydrochloride
CAS:
79559-97-0
MF:
C17H18Cl3N
Structure:
Chemical Name:
Lithium carbonate
CAS:
554-13-2
MF:
CLi2O3
Structure:
Chemical Name:
Amitriptyline hydrochloride
CAS:
549-18-8
MF:
C20H24ClN
Structure:
Chemical Name:
HEMATOPORPHYRIN DIHYDROCHLORIDE
CAS:
17696-69-4
MF:
C34H39ClN4O6
Structure:
Chemical Name:
Paroxetine hydrochloride
CAS:
78246-49-8
MF:
C19H21ClFNO3
Structure:
Chemical Name:
FLUOXETINE HYDROCHLORIDE
CAS:
59333-67-4
MF:
C17H19ClF3NO
Structure:
Chemical Name:
Doxepin hydrochloride
CAS:
1229-29-4
MF:
C19H22ClNO
Structure:
Chemical Name:
Clomipramine hydrochloride
CAS:
17321-77-6
MF:
C19H24Cl2N2
Structure:
Chemical Name:
Yohimbine
CAS:
146-48-5
MF:
C21H26N2O3
Structure:
Chemical Name:
Trazodone hydrochloride
CAS:
25332-39-2
MF:
C19H23Cl2N5O
Structure:
Chemical Name:
Sibutramine hydrochloride
CAS:
84485-00-7
MF:
C17H27Cl2N
Structure:
Chemical Name:
Moclobemide
CAS:
71320-77-9
MF:
C13H17ClN2O2
Structure:
Chemical Name:
Phenelzine
CAS:
51-71-8
MF:
C8H12N2
Structure:
Chemical Name:
Amitriptyline
CAS:
50-48-6
MF:
C20H23N
Structure:
Chemical Name:
PAROXETINE-D4 HCL
CAS:
110429-35-1
MF:
C19H17ClD4FNO3
Structure:
Chemical Name:
NORTRIPTYLINE
CAS:
72-69-5
MF:
C19H21N
Structure:
Chemical Name:
3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one
CAS:
7416-34-4
MF:
C16H24N2O2
Structure:
Chemical Name:
Phenelzine Sulfate
CAS:
156-51-4
MF:
C8H14N2O4S
Structure:
Chemical Name:
IMIPRAMINE
CAS:
50-49-7
MF:
C19H24N2
Structure:
Chemical Name:
Fluvoxamine maleate
CAS:
61718-82-9
MF:
C19H25F3N2O6
Structure:
Chemical Name:
DESIPRAMINE
CAS:
50-47-5
MF:
C18H22N2
Structure:
Chemical Name:
Fluoxetine
CAS:
54910-89-3
MF:
C17H18F3NO
Structure:
Chemical Name:
ISOCARBOXAZID (200 MG)
CAS:
59-63-2
MF:
C12H13N3O2
Structure:
Chemical Name:
Trazodone
CAS:
19794-93-5
MF:
C19H22ClN5O
Structure:
Chemical Name:
Metapramine
CAS:
21730-16-5
MF:
C16H18N2
Structure:
Chemical Name:
Mianserin hydrochloride
CAS:
21535-47-7
MF:
C18H21ClN2
Structure:
Chemical Name:
TRIMIPRAMINE
CAS:
739-71-9
MF:
C20H26N2
Structure:
Chemical Name:
DESIPRAMINE HYDROCHLORIDE
CAS:
58-28-6
MF:
C18H23ClN2
Structure:
Chemical Name:
DOXEPIN
CAS:
1668-19-5
MF:
C19H21NO
Structure:
Chemical Name:
Sertraline
CAS:
79617-96-2
MF:
C17H17Cl2N
Structure:
Chemical Name:
Clomipramine
CAS:
303-49-1
MF:
C19H23ClN2
Structure:
Chemical Name:
Paroxetine
CAS:
61869-08-7
MF:
C19H20FNO3
Structure:
Chemical Name:
Citalopram
CAS:
59729-33-8
MF:
C20H21FN2O
Structure:
Chemical Name:
Fluoxetine hydrochloride
CAS:
56296-78-7
MF:
C17H19ClF3NO
Structure:
Chemical Name:
NOMIFENSINE MALEATE
CAS:
24526-64-5
MF:
C16H18N2
Structure:
Chemical Name:
Sibutramine
CAS:
106650-56-0
MF:
C17H26ClN
Structure:
Chemical Name:
Asenapine
CAS:
65576-45-6
MF:
C17H16ClNO
Structure:
Chemical Name:
Maprotiline
CAS:
10262-69-8
MF:
C20H23N
Structure:
Chemical Name:
Maprotiline hydrochloride
CAS:
10347-81-6
MF:
C20H24ClN
Structure:
Chemical Name:
Reboxetine
CAS:
98769-81-4
MF:
C19H23NO3
Structure:
Chemical Name:
Melitracen
CAS:
5118-29-6
MF:
C21H25N
Structure:
Chemical Name:
NORTRIPTYLINE HYDROCHLORIDE
CAS:
894-71-3
MF:
C19H22ClN
Structure:
Chemical Name:
Fluvoxamine
CAS:
54739-18-3
MF:
C15H21F3N2O2
Structure:
Chemical Name:
Toloxatone
CAS:
29218-27-7
MF:
C11H13NO3
Structure:
Chemical Name:
Melitracen hydrochloride
CAS:
10563-70-9
MF:
C21H26ClN
Structure:
Chemical Name:
HEMATOPORPHYRIN
CAS:
14459-29-1
MF:
C34H38N4O6
Structure:
Chemical Name:
LITHIUM CITRATE
CAS:
919-16-4
MF:
C6H5Li3O7
Chemical Name:
Hematoprophyrin
MF:
C34H38N4O6
Chemical Name:
MOLINDONE HCL
Chemical Name:
NORTRIPTYLINE HCL(USP)(COMING SOON)(P)
Structure:
Chemical Name:
Mianserin
MF:
C18H20N2
Structure:
Chemical Name:
Flubanilate
CAS:
847-20-1
MF:
C14H19F3N2O2
Structure:
Chemical Name:
Carpipramine
CAS:
5942-95-0
MF:
C28H38N4O
Structure:
Chemical Name:
carpipramine dihydrochloride
CAS:
7075-03-8
MF:
C28H38N4O.2ClH.H2O