Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Nervous system drugs >  Antidepressants, Antimanics drugs >  Melitracen

Melitracen

Basic information Safety Supplier Related

Melitracen Basic information

Product Name:
Melitracen
Synonyms:
  • Dixeran
  • N-7001
  • Trausban
  • U-24973
  • 10563-70-9 (Hydrochloride)
  • 1-Propanamine, 3-(10,10-dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl- (9ci)
  • 9-(3-Dimetilaminopropyliden)-10,10-dimetil-9,10-diidroanthracene
  • 9-(3-Dimetilaminopropyliden)-10,10-dimetil-9,10-diidroanthracene [italian]
CAS:
5118-29-6
MF:
C21H25N
MW:
291.43
EINECS:
2258585
Mol File:
5118-29-6.mol
More
Less

Melitracen Chemical Properties

Boiling point:
423.43°C (rough estimate)
Density 
0.9801 (rough estimate)
refractive index 
1.4900 (estimate)
pka
9.18±0.28(Predicted)
NIST Chemistry Reference
1-Propanamine, 3-(10,10-dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl-(5118-29-6)
More
Less

Melitracen Usage And Synthesis

Originator

Trausabun,Lusofarma,W. Germany,1965

Uses

Antidepressant.

Definition

ChEBI: Melitracen is a member of anthracenes.

Manufacturing Process

24 g of 2-o-benzoylphenylpropanol-2 (MP 116°C) were dissolved in 250 ml of anhydrous ether and the resulting solution was added dropwise while stirring to a suspension of 0.22 mol of dimethylaminopropylmagnesium chloride in 100 ml of ether. The reaction mixture was refluxed for one hour on a steam bath, and water and dilute hydrochloric acid were added until the reaction was pH 4-5. The aqueous phase was separated and 60 ml of concentrated aqueous ammonia were added. The mixture was extracted with ether, and the ether phase was separated, dried and evaporated in a steam bath. The residue was dissolved in hot petroleum ether and the solution left standing to cool for some time, whereupon 4-dimethylamino-1-phenyl-1-[2-(2-hydroxy-2- propyl)phenyl]-butanol-1 crystallized out as white crystals which were sucked off. After drying they melted at 88°C to 90°C.
10 g of this compound were cautiously dissolved in 50 ml of concentrated sulfuric acid under cooling and the mixture was kept at room temperature for 24 hours, whereupon the reaction mixture was poured into 200 g of finely crushed ice, and concentrated aqueous ammonia was added to about pH 9, whereupon the oil which separated out was extracted with ether. The ether phase was separated, dried and the ether evaporated on a steam bath. The residue was dissolved in 20 ml of acetone and the solution neutralized with a solution of dry hydrogen chloride in ether. The white crystals of 9-γdimethylaminopropylidene-10,10-dimethyl-9,10-dihydroanthracene hydrochloride which separated out was filtered off and dried. Yield 9 g. MP 245°C to 247°C.

Therapeutic Function

Antidepressant

MelitracenSupplier

LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Email
lzz841106@aliyun.com
Amadis Chemical Company Limited
Tel
571-89925085
Email
sales@amadischem.com
Chengdu Saint - Kay Biotechnology Co., Ltd.
Tel
028-85157043 15882256948
Email
676046971@qq.com
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-037163312495,13303845143 13303845143
Email
3001379618@qq.com