H2N-PEG5-CH2COOH Chemical Properties

Boiling point:

434.2±40.0 °C(Predicted)

Density 

1.150±0.06 g/cm3(Predicted)

solubility 

DMSO : 20 mg/mL (67.72 mM; ultrasonic and warming and heat to 60°C)

pka

3.39±0.10(Predicted)

H2N-PEG5-CH2COOH Usage And Synthesis

Biological Activity

Amino-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

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