Basic information Safety Supplier Related

Amino-PEG4-acid

Basic information Safety Supplier Related

Amino-PEG4-acid Basic information

Product Name:
Amino-PEG4-acid
Synonyms:
  • 3-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]propionic acid
  • 1-AMino-3,6,9,12-tetraoxapentadecan-15-oic acid
  • Α-AMINE-Ω-PROPIONIC ACID TETRAETHYLENE GLYCOL
  • Amino-PEG4-acid
  • α-amine-ω-propionic acid tetraethylene glycol
  • alpha-aMine-oMega-propionic acid tetraethylene glycol
  • H2N-PEG4-CH2CH2COOH
  • Amino-dPEGx-acid
CAS:
663921-15-1
MF:
C11H23NO6
MW:
265.3
EINECS:
828-940-4
Product Categories:
  • PEG-COOH
  • peg
Mol File:
663921-15-1.mol
More
Less

Amino-PEG4-acid Chemical Properties

Boiling point:
409.6±40.0 °C(Predicted)
Density 
1.134±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
4.28±0.10(Predicted)
form 
powder
color 
White
InChI
InChI=1S/C11H23NO6/c12-2-4-16-6-8-18-10-9-17-7-5-15-3-1-11(13)14/h1-10,12H2,(H,13,14)
InChIKey
DKUZHSDZSMQOGQ-UHFFFAOYSA-N
SMILES
C(O)(=O)CCOCCOCCOCCOCCN
More
Less

Safety Information

HS Code 
2942000090
More
Less

Amino-PEG4-acid Usage And Synthesis

Description

Amino-PEG4-acid is a very popular PEG linker. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond, long PEG spacer increases reagent's solubility in aqueous media.

Uses

H2N-Dpeg(4)-COOH, can be used in optical imaging of integrin αvβ3 expression with near-infrared fluorescent RGD dimer with tetra(ethylene glycol) linkers. Integrin αvβ3 plays great roles in tumor angiogenesis, invasion, and metastasis.

benefits

Amino-dPEG4-acid has a primary amine and propionic acid terminating opposite ends of a 16-atoms long (18.0 ?) polyethylene glycol (PEG) spacer. The single molecular weight PEG spacer is discrete (D = 1). Moreover, it is highly hydrophilic, and it imparts hydrophilicity to conjugates that incorporate it. Amino-dPEG4-acid is useful in many different applications, including peptide synthesis, surface modification, dendrimer construction, and small molecule modification.

References

1. Improving tumor-targeting capability and pharmacokinetics of (99m)Tc-labeled cyclic RGD dimers with PEG(4) linkers. DOI:10.1021/mp800150r
2. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. DOI:10.1021/bc400050k
3. Microwave-mediated synthesis of labeled nucleotides with utility in the synthesis of DNA probes. DOI:10.1021/bc100013b
4. Improving tumor uptake and pharmacokinetics of (64)Cu-labeled cyclic RGD peptide dimers with Gly(3) and PEG(4) linkers. DOI:10.1021/bc800455p

Amino-PEG4-acidSupplier

Wuhan Augda Biotechnology Co., Ltd Gold
Tel
15071299552
Email
262933239@qq.com
Zhengzhou Convergence Chemical Co. LTD Gold
Tel
0371-53736046 13393710386
Email
2853979814@qq.com
Xi‘an Deeptech Biotechnology Co.,LTD Gold
Tel
+86-15114901355 +86-15114901355
Email
15114901355@163.com
Hangzhou HanLai Biochemical Technology Co., Ltd. Gold
Tel
571-86101219 18768477782
Email
sales09@leobiochem.com
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Email
sales@pharmablock.com