Basic information Safety Supplier Related

2-HYDROXYCINNAMALDEHYDE

Basic information Safety Supplier Related

2-HYDROXYCINNAMALDEHYDE Basic information

Product Name:
2-HYDROXYCINNAMALDEHYDE
Synonyms:
  • AKOS BC-1812
  • 2-HYDROXYCINNAMALDEHYDE
  • 3-(2-HYDROXYPHENYL)-2-PROPENAL
  • 2-hydroxycinnamicaldehyde
  • 3-(2-hydroxyphenyl)-2-propena
  • o-hydroxy-cinnamaldehyd
  • o-hydroxycinnamaldehyde
  • Hydroxycinnamaldehyde
CAS:
3541-42-2
MF:
C9H8O2
MW:
148.16
EINECS:
204-683-8
Mol File:
3541-42-2.mol
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2-HYDROXYCINNAMALDEHYDE Chemical Properties

Melting point:
126 °C
Boiling point:
311.3±17.0 °C(Predicted)
Density 
1.174±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
form 
Solid
pka
8.99±0.35(Predicted)
color 
Yellow to Dark Yellow
LogP
1.674 (est)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36-43
Safety Statements 
26-36/37
RTECS 
GD6565000
HS Code 
2912.49.2600
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2-HYDROXYCINNAMALDEHYDE Usage And Synthesis

Uses

2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits Wnt/β-catenin, STAT3 signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities[1][2][3].

Definition

ChEBI: (E)-3-(2-Hydroxyphenyl)-2-propenal is a member of cinnamaldehydes.

Synthesis Reference(s)

Synthetic Communications, 34, p. 1223, 2004 DOI: 10.1081/SCC-120030309

References

[1] Lee MA, et al. Antitumor activity of 2-hydroxycinnamaldehyde for human colon cancer cells through suppression of β-catenin signaling. J Nat Prod. 2013 Jul 26;76(7):1278-84. DOI:10.1021/np400216m
[2] Yoon YJ, et al. 2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2. Cancer Lett. 2018 Oct 10;434:42-55. DOI:10.1016/j.canlet.2018.07.015
[3] Hao Let al. 2'-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice. Exp Mol Med. 2021 May;53(5):875-884. DOI:10.1038/s12276-021-00620-z

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