MORIN Chemical Properties

Melting point:

299-300 °C (dec.)(lit.)

Boiling point:

363.28°C (rough estimate)

Density 

1.3616 (rough estimate)

refractive index 

1.4790 (estimate)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

methanol: 50 mg/mL

pka

6.30±0.40(Predicted)

Colour Index 

75660

form 

powder

color 

yellow

Water Solubility 

0.25g/L(20 ºC)

Merck 

6269

Stability:

Stable. Incompatible with strong oxidizing agents.

InChIKey

YXOLAZRVSSWPPT-UHFFFAOYSA-N

LogP

1.27-1.54 at 37℃ and pH7.4

CAS DataBase Reference

480-16-0(CAS DataBase Reference)

EPA Substance Registry System

Morin (480-16-0)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

36/37/38-25

Safety Statements 

26-36-45

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

RTECS 

LK8749000

F 

8-10-23

HS Code 

29329990

Toxicity

LD50 intraperitoneal in mouse: 555mg/kg

MSDS

• Language:English Provider:SigmaAldrich

MORIN Usage And Synthesis

Chemical Properties

yellow to brown powder

Uses

P450 and ATPase inhibitor

Uses

Morin is a natural pentahydroxyflavonol with antioxidant activity. It reduces CD36 expression and oxLDL uptake in U937-derived macrophages, inhibits PIM-1 kinase in vitro (IC50 = 2.7 μM), and reduces the activity of cytochrome P450 isoform 3A4 in liver microsomes. Through these and other actions, morin has anti-oxidant, anti-inflammatory, and other actions in animal models.[Cayman Chemical]

Uses

Morin is a polyphenolic flavonoid with radical scavenging ability. In addition it maintains the potential for suppression of lipopolysaccharide-induced neuroinflammation.

Definition

ChEBI: A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5.

Safety Profile

Moderately toxic by intraperitoneal route. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Stir morin at room temperature with ten times its weight of absolute EtOH, then leave overnight to settle. Filter it off, and evaporate under a heat lamp to one-tenth its volume. An equal volume of water is added, and the precipitated morin is filtered off, dissolved in the minimum amount of EtOH and again precipitated with an equal volume of water. The precipitate is filtered off, washed with water and dried at 110o for 1hour (yield ca 2.5%.). [Perkins & Kalkwarf Anal Chem 28 1989 1956.] It complexes with W and Zr. [Beilstein 18 H 239, 18 III/IV 3468, 18/5 V 492.]

MORIN(480-16-0)Related Product Information

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