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ISOQUERCITRIN

Basic information Safety Supplier Related

ISOQUERCITRIN Basic information

Product Name:
ISOQUERCITRIN
Synonyms:
  • anosyloxy)-
  • Isoquercitrin/Isoquercetin
  • glucosyl3-quercetin
  • hirsutrin
  • quercetin3-beta-glucoside
  • quercetin3-beta-o-glucoside
  • quercetin3-d-glucoside
  • quercetin3-monoglucoside
CAS:
482-35-9
MF:
C21H20O12
MW:
464.38
EINECS:
640-533-1
Product Categories:
  • Antineoplastic
Mol File:
482-35-9.mol
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ISOQUERCITRIN Chemical Properties

Melting point:
230 °C
Boiling point:
872.6±65.0 °C(Predicted)
Density 
1.87±0.1 g/cm3(Predicted)
FEMA 
4225 | ISOQUERCITRIN, ENZYMATICALLY MODIFIED
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
6.17±0.40(Predicted)
color 
Light Yellow to Yellow
Water Solubility 
slightly soluble in water
BRN 
100989
Stability:
Hygroscopic
InChIKey
OVSQVDMCBVZWGM-QSOFNFLRSA-N
LogP
1.750 (est)
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Safety Information

Hazard Codes 
Xi
Safety Statements 
24/25
WGK Germany 
3
RTECS 
LK8960000
10-23
HS Code 
29389090
Toxicity
LD50 intraperitoneal in mouse: > 5gm/kg

MSDS

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ISOQUERCITRIN Usage And Synthesis

Chemical Properties

White to Light Yellow Powder

Uses

Isoquercitrin was used as standard to compare the retention time of samples for identifying chromatographic peaks during flavonoid identification by Orbitrap UHPLC-MS/MS analysis.

Uses

Quercetin 3-β-D-glucoside has been used:

  • as a dietary flavonoid supplement to check its binding capacity with human small ubiquitin-related modifier 1 (SUMO1) protein using surface plasmon resonance (SPR)
  • as an inhibitor for Escherichia coli adenosine triphosphate (ATP) synthase
  • as an anti-aggregation agent to test its activity against β-amyloid, green fluorescent protein?(GFP), and chymotrypsinogen proteins

Definition

ChEBI: Quercetin 3-O-beta-D-glucopyranoside is a quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 3. Isolated from Lepisorus contortus, it exhibits antineoplastic activityand has been found to decrease the rate of polymerization and sickling of red blood cells It has a role as an antineoplastic agent, a plant metabolite, a bone density conservation agent, an osteogenesis regulator, an antioxidant, a histamine antagonist, an antipruritic drug and a geroprotector. It is a quercetin O-glucoside, a tetrahydroxyflavone, a beta-D-glucoside and a monosaccharide derivative. It is functionally related to a beta-D-glucose. It is a conjugate acid of a quercetin 3-O-beta-D-glucopyranoside(1-).

General Description

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Biochem/physiol Actions

Quercetin 3-β-D-glucoside possesses strong antioxidant and anti-inflammatory activities. Being a potent oxygen-radical scavenger, it is a neuroprotective agent that improves Alzheimer′s disease (AD) condition in mice models. It has shown antiproliferative activity against colon, lung, and hepatocellular cell lines and MCF-7 human breast cancer cells in combination with apple extracts.

ISOQUERCITRINSupplier

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