Basic information Safety Supplier Related

GOSSYPIN

Basic information Safety Supplier Related

GOSSYPIN Basic information

Product Name:
GOSSYPIN
Synonyms:
  • 3,3',4',5,7,8-HEXAHYDROXYFLAVONE 8-GLUCOSIDE
  • 3,3',4',5,7-PENTAHYDROXY-8-O-GLUCOSYLFLAVONE
  • GOSSYPIN
  • ,7-trihydroxy-
  • 2-(3,4-dihydroxyphenyl)-8-(beta-d-glucopyranosyloxy)-3,5,7-trihydroxy-4h-1-b
  • 4h-1-benzopyran-4-one,2-(3,4-dihydroxyphenyl)-8-(beta-d-glucopyranosyloxy)-3,5
  • gossypin from hibiscus vitifolius*flowers
  • COTTON CELLULOSE
CAS:
652-78-8
MF:
C21H20O13
MW:
480.38
Product Categories:
  • Flavanols
Mol File:
652-78-8.mol
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GOSSYPIN Chemical Properties

Melting point:
229-230°C
Boiling point:
886.0±65.0 °C(Predicted)
Density 
1.883±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
-20°C
solubility 
DMSO: soluble15mg/mL, clear
form 
powder
pka
5.70±0.40(Predicted)
color 
light yellow to dark green-yellow
LogP
-1.320 (est)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-62-37/38-36-22
Safety Statements 
26-36-37
WGK Germany 
3
RTECS 
DJ3009900
HS Code 
2938909090

MSDS

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GOSSYPIN Usage And Synthesis

Uses

antiinflammatory, antiangiogenesis, antineoplastic, inhibits NF-kB cell response

Definition

ChEBI: A glycosyloxyflavone that is gossypetin attached to a beta-D-glucopyranosyl residue at position 8 via a glycosidic linkage.

Biological Activity

Gossypin is an anti-inflammatory pentahydroxyflavone glucoside isolated from Hibiscus vitifolius th at is used as an herbal remedy for diabetes, jaundice, and inflammation. Gossypin potently inhibits human cancer cell proliferation, including melanoma and glioma cells. Gossypin directly binds and inhibits BRAFV600E and CDK4 kinases, and also regulates Chk1 and Cdc25C in U251 glioma cells.

in vivo

Gossypin (10-20 mg/kg; p.o.; 30 days) attenuates Isoprenaline (ISO) (HY-108353)-induced ischemic/reperfusion (I/R) in rats via alteration of oxidative stress, inflammatory reaction and gut microbiota[2].

Animal Model:Sprague Dawley (SD) rats (200-225 g; male; 8-10 weeks)[2]
Dosage:10, 20 mg/kg
Administration:Oral gavage (p.o.); 30 days
Result:Reduced the infarct size induced by Isoprenaline (ISO) (HY-108353).
Showed the boosted level of LVESP, SW, ESPVR, DP, EDPVR and suppressed level of LVEDP.
Increased the bodyweight and suppressed the heart weight and heart/body weight ratio.
Suppressed the level of triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL) and increased the level of high-density lipoprotein (HDL).
Suppressed the level of nitric oxide synthase (iNOS) and nitric oxide (NO).
Decreased the level of MMP-2 and MMP-9.
Suppressed the level of inflammatory cytokines (TNF-α, IL-1β, IL-6) and decreased the level of NF-κB in the serum and heart tissue.
Suppressed the apoptosis of muscle fibres with edema and necrosis.

GOSSYPIN Preparation Products And Raw materials

Preparation Products

Hydroxypropyl methyl cellulose

GOSSYPINSupplier

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sales@reading-chemicals.com
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GOSSYPIN(652-78-8)Related Product Information