2'-Hydroxy-5'-methoxyacetophenone Chemical Properties

Melting point:

52 °C(lit.)

Boiling point:

254.38°C (rough estimate)

Density 

1.1708 (rough estimate)

refractive index 

1.5500 (estimate)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Crystalline Powder

pka

10.65±0.18(Predicted)

color 

Yellow

Odor

Aromatic, somewhat medicinal, warm, woody -the herbaceous odour of good tenacity.

BRN 

1239364

InChIKey

MLIBGOFSXXWRIY-UHFFFAOYSA-N

CAS DataBase Reference

705-15-7(CAS DataBase Reference)

NIST Chemistry Reference

Ethanone, 1-(2-hydroxy-5-methoxyphenyl)-(705-15-7)

Safety Information

Hazard Codes 

Xi

Risk Statements 

37/38-41-36/37/38

Safety Statements 

26-37/39-36/37/39-22

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29145090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2'-Hydroxy-5'-methoxyacetophenone Usage And Synthesis

Chemical Properties

yellow crystalline powder

Uses

2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols. 2-Hydroxy-5-methoxyacetophenone is also used to prepare substituted chromanone and chromone derivatives as sirtuin 2-selective inhibitors.

Application

2'-Hydroxy-5'-methoxyacetophenone could find some use in perfume compositions, e. g., in artificial Oakmoss, in New Mown Hay fragrances, and in certain heavy florals. It blends well with Labdanum and with Lavender type oils, and it lends a certain amount of power and undertones to the fragrance.

Preparation

reparation by reaction of dimethyl sulfate on 2,5-dihydroxyacetophenone, ? with potassium carbonate in acetone at r.t. (74%) ; ? with aqueous sodium hydroxide solution at reflux (35%).

Synthesis Reference(s)

Synthesis, p. 901, 1985 DOI: 10.1055/s-1985-31380

General Description

2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols.

2'-Hydroxy-5'-methoxyacetophenone(705-15-7)Related Product Information

• 4'-Hydroxyacetophenone
• PIPERACETAZINE (250 MG)
• 2'-Methoxyacetophenone
• CHLOROPHOSPHONAZO III
• 3-Methoxyacetophenone
• 2',4'-Dichloroacetophenone
• 3-Aminoacetophenone
• 3',5'-Dimethoxyacetophenone
• 4-Nitroacetophenone
• 4'-Methoxyacetophenone
• 3,4-Dimethoxyacetophenone
• 2-HYDROXYACETOPHENONE
• Acetophenone
• 2'-Hydroxyacetophenone
• 3-Nitroacetophenone
• 2-BROMO-2',5'-DIMETHOXYACETOPHENONE
• EUPATORIN-5-METHYL ETHER
• 4',6,7-Trimethoxyisoflavone