2'-Hydroxy-5'-methoxyacetophenone Chemical Properties

Melting point:

52 °C(lit.)

Boiling point:

254.38°C (rough estimate)

Density 

1.1708 (rough estimate)

refractive index 

1.5500 (estimate)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Crystalline Powder

pka

10.65±0.18(Predicted)

color 

Yellow

BRN 

1239364

InChIKey

MLIBGOFSXXWRIY-UHFFFAOYSA-N

CAS DataBase Reference

705-15-7(CAS DataBase Reference)

NIST Chemistry Reference

Ethanone, 1-(2-hydroxy-5-methoxyphenyl)-(705-15-7)

Safety Information

Hazard Codes 

Xi

Risk Statements 

37/38-41-36/37/38

Safety Statements 

26-37/39-36/37/39-22

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29145090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2'-Hydroxy-5'-methoxyacetophenone Usage And Synthesis

Chemical Properties

yellow crystalline powder

Uses

2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols. 2-Hydroxy-5-methoxyacetophenone is also used to prepare substituted chromanone and chromone derivatives as sirtuin 2-selective inhibitors.

Preparation

reparation by reaction of dimethyl sulfate on 2,5-dihydroxyacetophenone, ? with potassium carbonate in acetone at r.t. (74%) ; ? with aqueous sodium hydroxide solution at reflux (35%).

Synthesis Reference(s)

Synthesis, p. 901, 1985 DOI: 10.1055/s-1985-31380

General Description

2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols.

2'-Hydroxy-5'-methoxyacetophenone(705-15-7)Related Product Information

• 4'-Hydroxyacetophenone
• PIPERACETAZINE (250 MG)
• 2'-Methoxyacetophenone
• CHLOROPHOSPHONAZO III
• 3-Methoxyacetophenone
• 2',4'-Dichloroacetophenone
• 3-Aminoacetophenone
• 3',5'-Dimethoxyacetophenone
• 4-Nitroacetophenone
• 4'-Methoxyacetophenone
• 3,4-Dimethoxyacetophenone
• 2-HYDROXYACETOPHENONE
• Acetophenone
• 2'-Hydroxyacetophenone
• 3-Nitroacetophenone
• 2-BROMO-2',5'-DIMETHOXYACETOPHENONE
• EUPATORIN-5-METHYL ETHER
• 4',6,7-Trimethoxyisoflavone