2'-Methoxyacetophenone Chemical Properties

Melting point:

117–119°C

Boiling point:

131 °C18 mm Hg(lit.)

Density 

1.09 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.5393(lit.)

FEMA 

4163 | 2-METHOXYACETOPHENONE

Flash point:

228 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Chloroform (Sparingly), Methanol (Sparingly)

form 

Liquid

color 

Clear slightly yellow to orange or slightly brown

Odor

at 1.00 % in propylene glycol. powdery anisic almond phenolic

Odor Type

anisic

Water Solubility 

immiscible

Sensitive 

Light Sensitive

JECFA Number

2042

BRN 

1100602

LogP

1.82

CAS DataBase Reference

579-74-8(CAS DataBase Reference)

NIST Chemistry Reference

Ortho-methoxyacetophenone(579-74-8)

EPA Substance Registry System

Ethanone, 1-(2-methoxyphenyl)- (579-74-8)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/38-36/37/38

Safety Statements 

37/39-26-36

WGK Germany 

3

TSCA 

Yes

HS Code 

29145000

MSDS

• Language:English Provider:2-Acetanisole
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2'-Methoxyacetophenone Usage And Synthesis

Chemical Properties

clear slightly yellow to orange or slightly

Chemical Properties

Colorless to pale yellow clear liquid; powdery anisic almond phenolic aroma.

Uses

2''-Methoxyacetophenone is a useful building block, often used in the preparation of chalcones, such as the chalcones of 3-benzylidene-2-chlorocyclohex-1-enecarbaldehyde for use as potential anti-proliferative agents.

Preparation

Preparation by reaction of dimethyl sulfate with o-hydroxyacetophenone in the presence of sodium hydroxide.

Aroma threshold values

Anisic-type, medium strength odor; recommend smelling in a 1.00% solution or less.

Taste threshold values

Powdery musty anisic almond taste at 30 ppm in water.

Synthesis Reference(s)

Tetrahedron Letters, 22, p. 2605, 1981 DOI: 10.1016/S0040-4039(01)90532-5
Journal of the American Chemical Society, 72, p. 5161, 1950 DOI: 10.1021/ja01167a100
The Journal of Organic Chemistry, 52, p. 150, 1987 DOI: 10.1021/jo00377a027

2'-Methoxyacetophenone(579-74-8)Related Product Information

• 2'-Hydroxyacetophenone
• 2',4'-Dichloroacetophenone
• 4-Nitroacetophenone
• o-Anisaldehyde
• 3-Nitroacetophenone
• Guaiacol
• Acetophenone
• 4'-Bromoacetophenone
• 3-Aminoacetophenone
• Dichloroacetonitrile
• 4'-Hydroxyacetophenone
• 4'-Ethoxyacetophenone
• 2-Bromoacetophenone
• 4'-Methoxyacetophenone
• 3,4-Dimethoxyacetophenone
• 3',5'-Dimethoxyacetophenone
• 3&#39-Methoxyacetophenone,3&#39-Methoxyacetophenone
• 2-Fluoro-4-methoxyacetophenone