2-Fluoro-4-methoxyacetophenone Chemical Properties

Melting point:

52-54 °C(lit.)

Boiling point:

80-85 °C (0.1 mmHg)

Density 

1.1410 (estimate)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

form 

Viscous Solution

color 

Clear colorless

Water Solubility 

Insoluble

BRN 

3539992

CAS DataBase Reference

74457-86-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29147000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Fluoro-4-methoxyacetophenone Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

2′-Fluoro-4′-methoxyacetophenone may be used in chemical synthesis.

Preparation

Obtained by reaction of acetic anhydride with 3-fluoroanisole in the presence of aluminium chloride in carbon disulfide at r.t., then at 30–35° until no more hydrochloric acid is evolved.

Synthesis

3-Fluoro-4-methoxyacetophenone oxime ether (39.4 mg, 0.2 mmol) was dissolved in 2 mL of ether, 37% hydrochloric acid was added and the reaction was stirred for 30 h at room temperature. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction solution was neutralized with saturated sodium carbonate solution to pH 7, followed by extraction of the mixture with ether (10 mL × 3). The organic phases were combined, dried with anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography (eluent ratio: petroleum ether/ethyl acetate = 20:1, v/v), and the eluent containing the target product was collected, and the solvent was removed by distillation under reduced pressure to afford 2-fluoro-4-methoxyacetophenone (26.5 mg, 79% yield).

References

[1] Patent: CN103922904, 2016, B. Location in patent: Paragraph 0058; 0059; 0062

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