Azido-PEG11-amine Chemical Properties

storage temp. 

Storage temp. -20°C

form 

clear liquid

color 

Colorless to Almost colorless

Safety Information

HS Code 

2942000090

Azido-PEG11-amine Usage And Synthesis

Description

Azido-PEG11-amine is a water soluble PEG compound. The azide group enables Click Chemistry. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG arm increases solubility in aqueous media.

Uses

Azido-PEG11-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG11-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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