1-azido-2-[2-(2-methoxyethoxy)ethoxy]ethane Chemical Properties

Boiling point:

58 °C(Press: 0.01 Torr)

Density 

1.08 g/mL

refractive index 

n/D 1.4472

storage temp. 

2-8°C

form 

liquid

color 

Colorless to light yellow

1-azido-2-[2-(2-methoxyethoxy)ethoxy]ethane Usage And Synthesis

Description

m-PEG3-azide is a PEG linker containing an azide group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

m-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

reaction suitability

reaction type: click chemistry

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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