m-PEG2-Azide Chemical Properties

storage temp. 

2-8°C

solubility 

Chloroform (Sparingly), Acetone (Slightly)

form 

Oil

color 

Pale Yellow to Light Yellow

m-PEG2-Azide Usage And Synthesis

Description

m-PEG2-azide is a PEG linker containing reactive azide group. The azide group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

Uses

m-PEG2-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

References

[1] Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67. DOI:10.3762/bjoc.11.74

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