Bis-Propargyl-PEG13 Chemical Properties

solubility 

Soluble in Water, DMSO, DMF, DCM

Bis-Propargyl-PEG13 Usage And Synthesis

Description

Bis-propargyl-PEG13 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

structure and hydrogen bonding

Bis-propargyl-PEG13 comprises two propargyl groups which can form triazole linkages with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions. The hydrophilic PEG units help improve the solubility of the molecule in aqueous media.

Bis-Propargyl-PEG13(1351373-50-6)Related Product Information

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