Bis-propargyl-PEG11 Chemical Properties

Boiling point:

593.3±45.0 °C(Predicted)

Density 

1.082±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

solubility 

Soluble in DMSO, DCM, DMF

form 

Solid

color 

Light yellow to brown

Bis-propargyl-PEG11 Usage And Synthesis

Description

Bis-propargyl-PEG12 has two alkyne groups at both ends of the linker. With the catalyzation of copper, the alkyne groups reacts with azide compounds to form stable triazole linkages. The PEG spacer enhances the water-solubility of the compound.

Uses

Bis-propargyl-PEG11 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bis-propargyl-PEG11 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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