Diethylene Glycol Bis(2-propynyl) Ether Chemical Properties

Boiling point:

103°C/6mmHg(lit.)

Density 

1.011±0.06 g/cm3(Predicted)

refractive index 

1.4610 to 1.4650

storage temp. 

Storage temp. 2-8°C

form 

clear liquid

color 

Colorless to Light yellow

Safety Information

HS Code 

2909.19.6000

Diethylene Glycol Bis(2-propynyl) Ether Usage And Synthesis

Description

Bis-propargyl-PEG3 is a crosslinker with alkyne groups at both ends of the molecule. The alkyne groups react with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry to form a stable triazole linkage.

Uses

Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers[1][2]. Bis-propargyl-PEG2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] Shenoi RA, et al. Synthesis, characterization, and biocompatibility of biodegradable hyperbranched polyglycerols from acid-cleavable ketal group functionalized initiators. Biomacromolecules. 2012 Oct 8;13(10):3018-30. DOI:10.1021/bm300959h
[2] Jiang, et al. Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis. Tetrahedron, 2018: 74(27), 3527–3533.

Diethylene Glycol Bis(2-propynyl) Ether(126422-57-9)Related Product Information

• Propargyl-PEG5-t-butyl ester
• 2-[2-(PROP-2-YNYLOXY)ETHOXY]ETHAN-1-OL
• Propargyl-PEG3-t-butyl ester
• Propargyl-PEG4-NHS ester
• propargyl-PEG3-Acid
• Propargyl-PEG3-NHS ester
• Propargyl-PEG5-alcohol
• Bis-propargyl-PEG10
• Bis-propargyl-PEG8
• Bis-Propargyl-PEG7
• Bis-propargyl-PEG11
• DIPROPARGYL ETHER
• Bis-Propargyl-PEG10
• Bis-Propargyl-PEG9
• Bis-Propargyl-PEG4
• alpha, oMega-Dipropionic acid triethylene glycol
• Bis-propargyl-PEG6
• 4,7,10,13,16-Pentaoxanonadeca-1,18-diyne