4,7,10,13,16-Pentaoxanonadeca-1,18-diyne Chemical Properties

Boiling point:

338.7±37.0 °C(Predicted)

Density 

1.043±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

form 

Liquid

color 

Colorless to light yellow

Safety Information

HS Code 

2909199090

4,7,10,13,16-Pentaoxanonadeca-1,18-diyne Usage And Synthesis

Description

Bis-propargyl-PEG5 is a crosslinker containing propargyl groups at both ends. The propargyl groups reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry to form stable triazole linkages.

Uses

Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers[1][2]. Bis-propargyl-PEG4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

References

[1] Pearlie BURNETTE, et al. Dimeric immuno-modulatory compounds against cereblon-based mechanisms. WO2020014489A2.
[2] Jiang, et al. Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis. Tetrahedron, 2018: 74(27), 3527–3533.

4,7,10,13,16-Pentaoxanonadeca-1,18-diyne(159428-42-9)Related Product Information

• Acetylene-PEG5-acid
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• 2-[2-(PROP-2-YNYLOXY)ETHOXY]ETHAN-1-OL
• Propargyl-PEG3-t-butyl ester
• Propargyl-PEG4-NHS ester
• propargyl-PEG3-Acid
• Propargyl-PEG3-NHS ester
• Propargyl-PEG5-alcohol
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• Bis-Propargyl-PEG9
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