Propargyl-PEG4-NHS ester CAS#: 1428629-70-2

Propargyl-PEG4-NHS ester Basic information

Product Name:

Propargyl-PEG4-NHS ester

Synonyms:

Propargyl-PEG4-NHS ester
Alkyne-PEG4-NHS
2,5-dioxopyrrolidin-1-yl 4,7,10,13-tetraoxahexadec-15-yn-1-oate
Propargyl-PEG3-CH2CH2COONHS
2,5-dioxopyrrolidin-1-yl 4,7,10,13-tetraoxahexadec-15-ynoate
Propargyl-PEG4-NHS ester,Alkyne-PEG4-NHS
4,7,10,13-Tetraoxahexadec-15-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester
Alkyne-PEG3-NHS ester

CAS:

1428629-70-2

MF:

C16H23NO8

MW:

357.36

Product Categories:

peg

Mol File:

1428629-70-2.mol

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Propargyl-PEG4-NHS ester Chemical Properties

Boiling point:: 463.1±55.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: Storage temp. -20°C
solubility: Soluble in DMSO, DCM, DMF
form: Viscous Liquid
color: Colorless to light yellow
Appearance: colorless to yellowish oil

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Propargyl-PEG4-NHS ester Usage And Synthesis

Description

Propargyl-PEG4-NHS ester is an amine reactive PEG linker with an alkyne group. Under the copper catalyzation, alkyne group can react with azide-bearing biomolecules to form a stable triazole linkage. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

Propargyl-PEG4-NHS ester is a nonclaevable 4-unit PEG linker for antibody-agent-conjugation (ADC). Propargyl-PEG4-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

Non-cleavable Linker

Propargyl-PEG4-NHS esterSupplier

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