Propargyl-PEG8-NHS ester
Propargyl-PEG8-NHS ester Basic information
- Product Name:
- Propargyl-PEG8-NHS ester
- Synonyms:
-
- Propargyl-PEG8-NHS ester
- Propargyl-PEG7-CH2CH2COONHS
- 4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester
- 2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16,19,22,25-octaoxaoctacos-27-yn-1-oate
- Propargyl-PEG7-C2-CONHS ester
- Propargyl-PEG7-CH2CH2COONHS/4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester
- CAS:
- 2182601-74-5
- MF:
- C24H39NO12
- MW:
- 533.57
- Mol File:
- 2182601-74-5.mol
Propargyl-PEG8-NHS ester Chemical Properties
- Boiling point:
- 593.4±60.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- solubility
- Soluble in DCM
- form
- Viscous Liquid
- color
- Colorless to light yellow
Propargyl-PEG8-NHS ester Usage And Synthesis
Description
Propargyl-PEG8-NHS ester is an amine reactive compound with an alkyne group. The alkyne group reacts with azide-containing biomolecules in Click Chemistry reactions, copper is needed as a catalyst. The hydrophilic PEG units helps the compound to have better solubility in aqueous environment.
Biological Activity
Propargyl-PEG8-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a range of PROTAC molecules. And it is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
| Alkyl/ether
|
Propargyl-PEG8-NHS esterSupplier
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