Basic information Safety Supplier Related

Propargyl-PEG8-NHS ester

Basic information Safety Supplier Related

Propargyl-PEG8-NHS ester Basic information

Product Name:
Propargyl-PEG8-NHS ester
Synonyms:
  • Propargyl-PEG8-NHS ester
  • Propargyl-PEG7-CH2CH2COONHS
  • 4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester
  • 2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16,19,22,25-octaoxaoctacos-27-yn-1-oate
  • Propargyl-PEG7-C2-CONHS ester
  • Propargyl-PEG7-CH2CH2COONHS/4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester
CAS:
2182601-74-5
MF:
C24H39NO12
MW:
533.57
Mol File:
2182601-74-5.mol
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Propargyl-PEG8-NHS ester Chemical Properties

Boiling point:
593.4±60.0 °C(Predicted)
Density 
1.21±0.1 g/cm3(Predicted)
solubility 
Soluble in DCM
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Propargyl-PEG8-NHS ester Usage And Synthesis

Description

Propargyl-PEG8-NHS ester is an amine reactive compound with an alkyne group. The alkyne group reacts with azide-containing biomolecules in Click Chemistry reactions, copper is needed as a catalyst. The hydrophilic PEG units helps the compound to have better solubility in aqueous environment.

Biological Activity

Propargyl-PEG8-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a range of PROTAC molecules. And it is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs

Alkyl/ether

Propargyl-PEG8-NHS esterSupplier

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