Propargyl-PEG13-acid CAS#: 1421676-62-1

Propargyl-PEG13-acid Basic information

Product Name:

Propargyl-PEG13-acid

Synonyms:

Propargyl-PEG13-acid
CAS_1421676-62-1
Propargyl-PEG25-acid
Propargyl-PEG-acid
Poly(oxy-1,2-ethanediyl), α-(2-carboxyethyl)-ω-(2-propyn-1-yloxy)-
Propargyl-PEG12-CH2CH2COOH

CAS:

1421676-62-1

MF:

(C2H4O)nC6H8O3

MW:

0

Mol File:

1421676-62-1.mol

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Propargyl-PEG13-acid Chemical Properties

solubility: Soluble in Water, DMSO, DCM, DMF

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Propargyl-PEG13-acid Usage And Synthesis

Description

Propargyl-PEG13-acid consists of an alkyne group and a carboxylic acid. The carboxylic acid reacts with amine groups to form amide bonds in the presence of EDC or HATU as an activator. The alkyne group is commonly used in copper catalyzed azide-alkyne Click Chemistry reactions. The hydrophilic PEG units enhance the solubility of the molecule in aqueous media.

Uses

Propargyl-PEG-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

Propargyl-PEG13-acidSupplier

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