propargyl-PEG3-Acid Chemical Properties

storage temp. 

-20°C

solubility 

Soluble in Water, DMSO, DCM, DMF

form 

clear liquid

color 

Light yellow to Brown

Safety Information

HS Code 

2918.99.5000

propargyl-PEG3-Acid Usage And Synthesis

Description

Propargyl-PEG3-acid is a reagent with an alkyne group and a carboxylic acid. The terminal carboxylic acid can form amide bond with primary amines (activation is needed). The alkyne can form triazole linkage with azide containing molecules via copper catalyzed reactions.

Uses

Propargyl-PEG₃-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG₃-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

propargyl-PEG3-Acid(1347760-82-0)Related Product Information

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